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    1. Neuroscience

    Taste quality and hunger interactions in a feeding sensorimotor circuit

    Philip K Shiu, Gabriella R Sterne ... Kristin Scott
    Gustatory information and hunger state impinge on a local, multilayered circuit that drives feeding initiation.
    1. Neuroscience

    More homogeneous capillary flow and oxygenation in deeper cortical layers correlate with increased oxygen extraction

    Baoqiang Li, Tatiana V Esipova ... Sava Sakadžić
    Resting-state capillary blood flow and oxygenation are more homogeneous in the deeper cortical layers, underpinning an important mechanism by which the microvascular network adapts to an increased local oxidative metabolism.
    1. Neuroscience

    Multiple decisions about one object involve parallel sensory acquisition but time-multiplexed evidence incorporation

    Yul HR Kang, Anne Löffler ... Michael N Shadlen
    When making two decisions about one object, two streams of information can be acquired in parallel but must be incorporated into the two decisions serially, consistent with a central bottleneck.
    1. Neuroscience

    Demixed principal component analysis of neural population data

    Dmitry Kobak, Wieland Brendel ... Christian K Machens
    A new data analysis tool provides a concise way of visualizing neural data that summarizes all the relevant features of the population response in a single figure.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The whale shark genome reveals patterns of vertebrate gene family evolution

    Milton Tan, Anthony K Redmond ... Timothy Read
    The new whale shark genome assembly represents the best gapless chondrichthyan genome assembly yet, and comparative genomic analyses provide insights into the evolution of vertebrate genome origins, immunity, and gigantism.
    1. Neuroscience
    2. Physics of Living Systems

    Gigapixel imaging with a novel multi-camera array microscope

    Eric E Thomson, Mark Harfouche ... Eva A Naumann
    A new multi camera imaging platform simultaneously captures large-area, high-resolution video of unconstrained small model organisms and provides behavioral measurements that span multiple spatial scales.
    1. Neuroscience

    What do adversarial images tell us about human vision?

    Marin Dujmović, Gaurav Malhotra, Jeffrey S Bowers
    Well-controlled psychological experiments show that there is little overlap in how humans and convolutional networks classify adversarial images, highlighting the problem of using CNNs as models of human vision.
    1. Neuroscience

    AVN: A Deep Learning Approach for the Analysis of Birdsong

    Therese MI Koch, Ethan S Marks, Todd F Roberts
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Structural Biology and Molecular Biophysics

    All-atom molecular dynamics simulations of Synaptotagmin-SNARE-complexin complexes bridging a vesicle and a flat lipid bilayer

    Josep Rizo, Levent Sari ... Milo M Lin
    Novel insights into the molecular mechanisms underlying neurotransmitter release are provided by all-atom molecular dynamics simulations including SNARE proteins, synaptotagmin-1, complexin-1, a vesicle and a flat bilayer.
    1. Chromosomes and Gene Expression

    Evidence that Mediator is essential for Pol II transcription, but is not a required component of the preinitiation complex in vivo

    Natalia Petrenko, Yi Jin ... Kevin Struhl
    Mediator, a transcriptional coactivator complex, is essential for transcription but is not a required component of a functional preinitiation complex, indicating that Mediator is not equivalent to a general transcription factor.