Long-term physical exercise had a substantial effect on the plasma proteome, identifying novel exerkines and suggesting CD300LG as a potential link to insulin sensitivity.
Copy number alteration heterogeneity exists in many shapes and forms in breast cancer genomes and single-cell genomics is a powerful tool to further our understanding of its nature and significance.
Akashdip Singh, Alberto Miranda Bedate ... Linde Meyaard
A bioinformatics pipeline describes 390 putative, novel inhibitory receptors, to facilitate targeted therapeutic strategies for diverse immune cell types in cancer therapy.
Robert Kiewisz, Gunar Fabig ... Thomas Müller-Reichert
Comprehensive 3D electron tomography reconstructions of metaphase spindles in human tissue culture cells reveal that kinetochore-fibers broaden as they extend polewards, forming semi-direct connections to the pole, where they preferentially interact with the spindle network.
Gut macrophages produce complement component C1q, which modulates neurogenic activity of gut peristalsis and is thus a key regulator of gastrointestinal motility.
Michael A Hahn, Dominik Heib ... Randolph F Helfrich
An individualized cross-frequency coupling approach identified slow oscillation-spindle coupling strength as a novel mechanism that mediates memory formation during cortical maturation.
Sleep spindles provide a temporal framework to organize the reactivation of behaviorally relevant CA1 cells and sparsely active cells in the limbic thalamus.
Anders S Hansen, Maxime Woringer ... Xavier Darzacq
Spot-On is an easy-to-use website that makes a rigorous and bias-corrected modeling framework for analysis of single-molecule tracking experiments available to all.
Marina Ainciburu, Teresa Ezponda ... Felipe Prosper
Single-cell transcriptomics reveals altered pathways, gene expression dynamics, and activation of transcriptional programs in human early hematopoiesis during healthy aging and myelodysplastic syndromes.
