4,105 results found
    1. Neuroscience

    Chronic 2P-STED imaging reveals high turnover of dendritic spines in the hippocampus in vivo

    Thomas Pfeiffer et al.
    Super-resolution STED microscopy is demonstrated for the first time in the deeply embedded mouse hippocampus in vivo, revealing direct evidence for an unprecedentedly high level of synapse remodeling in a brain structure closely associated with memory processing.
    1. Neuroscience

    Uncovering temporal structure in hippocampal output patterns

    Kourosh Maboudi et al.
    Machine learning models of coordinated hippocampal ensemble activity during sharp wave ripple activity encode structure that mirrors the place cell map expressed during exploration, and enable a new paradigm for analyzing and understanding this offline activity.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    BMP and FGF signaling interact to pattern mesoderm by controlling basic helix-loop-helix transcription factor activity

    Richard H Row et al.
    Interplay between FGF-induced bHLH transcription factors and BMP-induced bHLH inhibitory id genes govern mesodermal cell fate choice along the mediolateral axis in both zebrafish and mouse.
    1. Cell Biology

    Nicotinamide adenine dinucleotide is transported into mammalian mitochondria

    Antonio Davila et al.
    Stable isotope labeling reveals that NAD crosses the inner membrane of mammalian mitochondria via an unknown transporter.
    1. Neuroscience

    PACAP neurons in the ventral premammillary nucleus regulate reproductive function in the female mouse

    Rachel A Ross et al.
    Genetic and pharmacological approaches demonstrate that pituitary adenylate cyclase-activating polypeptide neurons from the ventral premamillary nucleus of the hypothalamus regulate reproductive function by modulating the activity of a subset of Kiss1 neurons in the female mouse.
    1. Epidemiology and Global Health

    Predicting the likelihood and intensity of mosquito infection from sex specific Plasmodium falciparum gametocyte density

    John Bradley et al.
    Malaria transmission between human and mosquito depends on the number of male and female gametocytes in the blood.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Computational design of thermostabilizing point mutations for G protein-coupled receptors

    Petr Popov et al.
    A comprehensive approach to prediction of stabilizing mutations in G-protein coupled receptors yields high hit rate and crystal structures of 5HT2C in both active and inactive states.
    1. Neuroscience

    Mediodorsal thalamus is required for discrete phases of goal-directed behavior in macaques

    Evan Wicker et al.
    Transient suppression of activity in the macaque mediodorsal thalamus impairs adjustment of secondary reinforcer values and disrupts appropriate action selection in a reinforcer devaluation task; this profile is distinct from that of amygdala or subregions of orbitofrontal cortex.
    1. Chromosomes and Gene Expression
    2. Developmental Biology
    3. Stem Cells and Regenerative Medicine

    SET-9 and SET-26 are H3K4me3 readers and play critical roles in germline development and longevity

    Wenke Wang et al.
    Two SET-domain containing proteins regulate H3K4me3 by their binding to H3K4me3 through their PHD domain and directly regulate expression of a subset of genes.
    1. Neuroscience

    Rem2 stabilizes intrinsic excitability and spontaneous firing in visual circuits

    Anna R Moore et al.
    In vivo and ex vivo analysis of the activity-regulated gene Rem2 in the mouse visual system sheds new light on the contribution of intrinsic excitability in circuit plasticity.

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