5,438 results found
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Contractile acto-myosin network on nuclear envelope remnants positions human chromosomes for mitosis

    Alexander JR Booth et al.
    Live-cell imaging shows that the contractile acto-myosin network on the nuclear envelope remnant positions chromosomes in early mitosis to ensure efficient and correct interactions between chromosomes and the mitotic spindle.
    1. Neuroscience

    Neuronal integration in the adult mouse olfactory bulb is a non-selective addition process

    Jean-Claude Platel et al.
    Adult neurogenesis in the olfactory bulb is not a turnover system but represents a lifelong neuronal addition mechanism.
    1. Developmental Biology
    2. Neuroscience

    Anterior CNS expansion driven by brain transcription factors

    Jesús Rodriguez Curt et al.
    The expansion of the anterior Drosophila CNS is driven by increased progenitor generation and prolonged proliferation, mediated by brain-restricted genes and the PRC2.
    1. Biochemistry and Chemical Biology

    An explanation for origin unwinding in eukaryotes

    Lance D Langston, Michael E O'Donnell
    CMG helicase translocates with force while encircling duplex DNA, enabling two opposing CMG complexes at an origin to melt the duplex and switch to encircling separate single strands.
    1. Neuroscience

    Active information maintenance in working memory by a sensory cortex

    Xiaoxing Zhang et al.
    Delay-period activity of anterior piriform cortex is important for working memory tasks requiring active maintenance and encodes the maintained information.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Proteome-wide signatures of function in highly diverged intrinsically disordered regions

    Taraneh Zarin et al.
    Widespread, rapidly evolving disordered regions contain molecular features that are preserved over evolution and are associated with specific biological functions.
    1. Cell Biology

    The transcription factor Hey and nuclear lamins specify and maintain cell identity

    Naama Flint Brodsly et al.
    Hey together with LaminC continuously supervise nuclear organisation and differentiated enterocyte identity, a regulation that is lost upon ageing, resulting in loss of gut homeostasis.
    1. Microbiology and Infectious Disease

    The microbiota protects from viral-induced neurologic damage through microglia-intrinsic TLR signaling

    D Garrett Brown et al.
    Immune stimulation from the microbiota prevents neurological damage associated with viral infection of the central nervous system.
    1. Ecology

    Algal-fungal symbiosis leads to photosynthetic mycelium

    Zhi-Yan Du et al.
    The capacity for symbiosis between photosynthetic microalgae and early diverging lineages fungi was demonstrated with microscopy and stable isotope exchange of carbon and nitrogen.
    1. Cell Biology
    2. Neuroscience

    Expression of WIPI2B counteracts age-related decline in autophagosome biogenesis in neurons

    Andrea KH Stavoe et al.
    The dynamic phosphorylation of autophagy component WIPI2B is critical to maintain autophagosome biogenesis in neurons, and ectopic expression of WIPI2B can restore rates of autophagosome biogenesis in aged neurons.

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