Precise dosage of the imprinted H19 and Igf2 genes is critical for normal embryonic development, especially related to the cardiac-placental axis.

A time-course of single nuclei RNA-seq of the mouse placenta identifies trophoblast subtypes and the genes, signaling events, and transcriptional networks important for their differentiation, maintenance, and function.

VE-cadherin is required for trophoblast invasion of the maternal decidua and spiral arteries.

Growth-delayed offspring generated from eggs that lacked normal epigenetic programming exhibited a remarkable capacity to undergo late gestational fetal growth recovery, despite inefficient placental function.

The short-lived tammar wallaby placenta expresses genes resembling eutherian placentas, establishing marsupials as "placental mammals", further, dynamic lactation allows marsupials to compensate for short placentation by expressing key placental genes in the mammary gland.

Investigation of mouse models from forward mutagenetic screen reveals that the gene Spag7 is essential for embryonic development and energy homeostasis later in life.

Epigenomic and transcriptomic analysis reveals that paternal obesity influences sperm histone H3 lysine 4 tri-methylation enrichment and placenta gene expression, which in turn negatively impact its development and function in a manner that may contribute to metabolic disease in offspring.

Machine learning identified six protective antibody features and showed for the first time that serological markers can predict protection from placental-malaria, which is important for evaluation and development of vaccines.

The incus of the middle ear plays a role in supporting the lower jaw prior to the formation of the mammalian jaw joint allowing early feeding in monotremes and marsupials.

Naive hPSCs can readily give rise to human trophoblast stem cells, thus demonstrating their extraembryonic lineage potential and providing a new model system to study human trophectoderm specification.