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    1. Plant Biology

    Structural basis for plant plasma membrane protein dynamics and organization into functional nanodomains

    Julien Gronnier et al.
    Unprecedented resolution of the molecular mechanisms of plant membrane protein anchoring involving phospholipids and sterols reveals the control of spatio-temporal segregation into plasma membrane nanodomains.
    1. Neuroscience
    2. Physics of Living Systems

    The neuronal calcium sensor Synaptotagmin-1 and SNARE proteins cooperate to dilate fusion pores

    Zhenyong Wu et al.
    During neurotransmitter release, calcium-induced membrane insertion of the C2B domain of Synaptotagmin re-orients the bound SNARE complex which dilates the fusion pore in a mechanical lever action.
    1. Cell Biology

    Reconstitution of self-organizing protein gradients as spatial cues in cell-free systems

    Katja Zieske, Petra Schwille
    A minimal cell-like system with defined geometry has been used to investigate the establishment and spatial control of a protein gradient that positions the bacterial cell division machinery.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The GIRK1 subunit potentiates G protein activation of cardiac GIRK1/4 hetero-tetramers

    Kouki K Touhara et al.
    The GIRK1 subunit contains a defective Na+-binding site but behaves as if it is permanently bound to a sodium ion, and therefore increases the affinity of Gβγ to GIRK1/4 hetero-tetrameric channels in lipid membranes.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Quantitative analysis of mammalian GIRK2 channel regulation by G proteins, the signaling lipid PIP2 and Na+ in a reconstituted system

    Weiwei Wang et al.
    The G protein subunits Gβγ and the signaling lipid PIP2 are simultaneously needed to activate the potassium ion channel GIRK2 to control the voltage across a lipid bilayer, while sodium ions modulate these molecules' effects.
    1. Biochemistry and Chemical Biology

    Membranes linked by trans-SNARE complexes require lipids prone to non-bilayer structure for progression to fusion

    Michael Zick et al.
    Lipids with a propensity to form nonbilayer structures must be present for the last step of membrane fusion to take place.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The fluoride permeation pathway and anion recognition in Fluc family fluoride channels

    Benjamin C McIlwain et al.
    In the extremely selective fluoride channels from the bacterial Fluc family, fluoride ions access the pore via two points, an electropositive vestibule and a triad of conserved residues involved in anion recognition.
    1. Immunology and Inflammation

    Composition and structure of synaptic ectosomes exporting antigen receptor linked to functional CD40 ligand from helper T cells

    David G Saliba et al.
    TCR and CD40L microclusters are linked in synaptic ectosomes (extracellular vesicles) and released in the immunological synapse by helper T cells and induce dendritic cell maturation and cytokine production.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients

    Lakshmi E Miller-Vedam et al.
    Structure-function characterization of the EMC's cytoplasmic, transmembrane, and lumenal domains reveal features critical for terminal helix insertion and a specialized role for the lumenal domain in polytopic membrane protein biogenesis.
    1. Structural Biology and Molecular Biophysics

    Model for a novel membrane envelope in a filamentous hyperthermophilic virus

    Peter Kasson et al.
    A novel membrane, formed by a monolayer of lipids in a U-shaped conformation, envelops a virus that can withstand extremes of temperature and acidity.