355 results found
    1. Epidemiology and Global Health
    2. Plant Biology

    Plant Pathology: Plasmid-powered evolutionary transitions

    Ryan A Melnyk, Cara H Haney
    The acquisition of a virulence plasmid is sufficient to turn a beneficial strain of Rhodococcus bacteria into a pathogen.
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    1. Developmental Biology

    The Natural History of Model Organisms: An organismal perspective on C. intestinalis development, origins and diversification

    Matthew J Kourakis, William C Smith
    The life cycle and morphology of the sea squirt Ciona intestinalis shed light on vertebrate evolution.
  1. Philosophy of Biology: Health, ecology and the microbiome

    S Andrew Inkpen
    The interactions between communities of microbial species and their human hosts raise questions about the nature of health and disease.
    1. Human Biology and Medicine
    2. Neuroscience

    Point of View: Predictive regulation and human design

    Peter Sterling
    Why does the human regulatory system, which evolution tuned for small satisfactions, now constantly demand 'more'?
    1. Cell Biology
    2. Computational and Systems Biology

    Science Forum: The Human Cell Atlas

    Aviv Regev et al.
    Advances in techniques for analysing single cells and tissues have inspired an international effort to create comprehensive reference maps of all human cells - the fundamental units of life - as a basis for both understanding human health and diagnosing, monitoring and treating disease.
  2. Scientist and Parent: Planning during pregnancy

    Bridget M Kuehn
    Colleagues, funders and institutions can support pregnant researchers in a variety of ways.
    1. Genetics and Genomics

    Genomics: The early days of late blight

    Paul RJ Birch, David EL Cooke
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  3. Point of View: A recipe for mediocrity and disaster, in five axioms

    Henry R Bourne
    Biomedical research in the US will become unsustainable unless scientists and research institutions start to question certain assumptions they have long taken for granted.
    1. Cell Biology

    A pathway for Parkinson’s Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain

    Herschel S Dhekne et al.
    Pathogenic LRRK2kinase requires Rab10 and RILPL1 to block primary cilia formation, shortening cilia on cholinergic neurons needed for a hedgehog driven circuit that supports dopaminergic neurons in mouse brain.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Embryonic hematopoiesis modulates the inflammatory response and larval hematopoiesis in Drosophila

    Wael Bazzi et al.
    Distinct hematopoietic waves interact via transcriptional cascades specific to embryonic hemocytes to ensure the proper immune response in Drosophila.​.

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