325 results found
    1. Computational and Systems Biology

    Essential metabolism for a minimal cell

    Marian Breuer et al.
    A near-complete flux balance analysis model of a minimal cell demonstrates the high essentiality of its metabolic genes, agrees well with experimental essentiality data and suggests some further gene removals.
  1. Philosophy of Biology: Health, ecology and the microbiome

    S Andrew Inkpen
    The interactions between communities of microbial species and their human hosts raise questions about the nature of health and disease.
    1. Neuroscience

    Selective targeting of unipolar brush cell subtypes by cerebellar mossy fibers

    Timothy S Balmer, Laurence O Trussell
    Distinct inputs to the cerebellum make contact on specific subtypes of target neurons.
    1. Neuroscience

    Developmental NMDA receptor dysregulation in the infantile neuronal ceroid lipofuscinosis mouse model

    Kevin P Koster et al.
    NMDA receptor function is regulated by protein depalmitoylation during visual cortical maturation and is dysfunctional in infantile neuronal ceroid lipofuscinosis.
    1. Cell Biology

    An ESCRT-LEM protein surveillance system is poised to directly monitor the nuclear envelope and nuclear transport system

    David J Thaller et al.
    ESCRT-driven mechanisms that sense and seal holes in the nuclear membranes directly monitor the nuclear transport system and the exposure of the inner nuclear membrane.
    1. Structural Biology and Molecular Biophysics

    The phage L capsid decoration protein has a novel OB-fold and an unusual capsid binding strategy

    Rebecca L Newcomer et al.
    The structure of phage L's Dec demonstrates a new fold within this family of proteins, and shows modulation of capsid binding occurs through two sites, with site 1 being preferred.
    1. Chromosomes and Gene Expression

    The RNA helicase UPF1 associates with mRNAs co-transcriptionally and is required for the release of mRNAs from gene loci

    Anand K Singh et al.
    UPF1 associates with nascent transcripts and plays a broad role in nuclear processes of gene expression.
    1. Cancer Biology

    Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells

    Simone Lieb et al.
    Targeting Werner syndrome helicase might constitute a novel opportunity for the treatment of a clinically defined subset of patients harboring MSI-H/MMR-deficient tumors.
    1. Cell Biology

    Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology

    Peipei Zhang et al.
    OptoGranules reveal the function of G3BP1 as a stress granule scaffold and demonstrate that protracted stress granule assembly is sufficient to drive neurodegeneration and the evolution of ALS-FTD pathology.
    1. Cell Biology
    2. Developmental Biology

    Anillin regulates epithelial cell mechanics by structuring the medial-apical actomyosin network

    Torey R Arnold et al.
    In epithelial cells, anillin organizes the medial-apical actomyosin cortex into a contractile load-bearing structure and increases tissue-level stiffness.

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