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Comprehensive machine learning analysis of
behavior reveals a stable basal behavioral repertoire
Shuting Han et al.
A novel automated behavior analysis method for
identifies pre-defined and new behavior types, and reveals a stable behavior repertoire.
Orphan receptor GPR158 controls stress-induced depression
Laurie P Sutton et al.
The orphan receptor GPR158 is highly regulated by stress exposure and acts on key neuronal signaling pathways in the prefrontal cortex to control depressive-like behaviors.
Replication Study: Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia
Xiaochuan Shan et al.
Editors' Summary: This Replication Study has reproduced important parts of the original paper.
Chromosomes and Gene Expression
Human Biology and Medicine
Mutations in L-type amino acid transporter-2 support
as a novel gene involved in age-related hearing loss
Meritxell Espino Guarch et al.
SLC7A8 a neutral amino acid transporter has a key role in the maintenance of hearing during aging and its absence causes early onset of hearing loss.
Computational and Systems Biology
Genetics and Genomics
Hsp70-associated chaperones have a critical role in buffering protein production costs
Zoltán Farkas et al.
Protein biosynthesis and protein quality control jointly determine protein production costs.
Diagnostic potential for a serum miRNA neural network for detection of ovarian cancer
Kevin M Elias et al.
Application of machine learning to serum miRNA profiles generated through next generation sequencing identifies a biologically relevant miRNA signature which can be deployed as a qPCR test to assist the diagnosis of epithelial ovarian cancer.
Genetics and Genomics
The genome of the crustacean
a model for animal development, regeneration, immunity and lignocellulose digestion
Damian Kao et al.
The first malacostracan genome sequence will establish the genetically tractable
as a model organism in this key animal group.
YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis
Chuwen Lin et al.
The control of local cell properties such as epithelial cell number and mechanical force production by Hippo signaling is a major determinant of lung branching.
Stem Cells and Regenerative Medicine
Embryonic hematopoiesis modulates the inflammatory response and larval hematopoiesis in
Wael Bazzi et al.
Distinct hematopoietic waves interact via transcriptional cascades specific to embryonic hemocytes to ensure the proper immune response in Drosophila..
Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone
Elizabeth A Gould et al.
Mild myelin disruption leads to early axonal pathology, a novel pathological response in neural stem cells, regionally increased oligodendrocytes and altered behavior.
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