In-built competing effects are present at different levels in signaling networks, starting from basic biochemical building blocks to the network level, and mathematical and computational analysis reveals when they give rise to biphasic responses and what the consequences are.
Paloma Diaz-Maroto, Alba Rey-Iglesia ... Anders J Hansen
aDNA revealed a model of domestication where an ancient guanaco population no longer exists, the loss of the ancient vicuña genetic variation in the modern populations, and frequently interbreeding practices.
Comprehensive analyses of amylase duplications and salivary activity across mammals underscore the importance of recurrent copy number variation as a flexible and rapid evolutionary mechanism.
Vasileios Kargas, Pablo Castro-Hartmann ... Alan John Warren
Cryo-EM reveals how the central functional site of the ribosome is assembled and provides a framework to interpret the consequences of mutations linked to leukaemia-associated ribosomopathies.
The cisternae of the Golgi contain two functionally distinct domains: the central areas, which remain stationary, and the edges or rims, which are mobile.
Jan Janouškovec, Gita G Paskerova ... Timur G Simdyanov
Apicomplexan-like parasites originated several times independently and many of them contain cryptic plastid organelles, which demonstrate that the parasites evolved from photosynthetic algae.
A novel DNA/RNA modifying enzyme catalyzing a previously unknown 5-carbamoyloxymethylcytosine modification has been discovered using a novel framework called Metagenomics Genome-Phenome Association.
Jonathon Alexis Coates, Elliot Brooks ... Iwan Robert Evans
Drosophila macrophages are a heterogeneous population of cells containing subpopulations with enhanced responses to injury that display considerable variation in their abundance across development.
Worm holocentromeres show a polycentric distribution, with each site containing a single centromeric nucleosome and also being targeted by multiple transcription factors.
