Identification of causal genes and their effects on other biological determinants untangles the complexities of aging and Alzheimer's and can facilitate drug discovery for sustaining healthy aging and treating Alzheimer's.
In models of chronic migraine, neuronal complexity is diminished in head-pain processing regions but restored through HDAC6 inhibition, which increases tubulin acetylation and cytoskeletal flexibility, and CGRP receptor blockade.
Lack of OPA1 in BAT impairs its thermogenic activation and induces endoplasmic reticulum stress, while improving systemic metabolism and thermoregulation via ATF4-FGF21-dependent and -independent mechanisms.
ATG9-dependent autophagy is an essential pathway for long-term survival within the cyst in the parasite Toxoplasma gondii and could be exploited in future studies seeking interventions against persistent Toxoplasma infection.
Artificial selection for increased tibia length in mice made their skulls longer, narrower, and flatter, suggesting that even distant skeletal regions can evolve as correlated responses to selection acting locally.