3,502 results found
    1. Computational and Systems Biology
    2. Human Biology and Medicine

    In-depth human plasma proteome analysis captures tissue proteins and transfer of protein variants across the placenta

    Maria Pernemalm et al.
    Comprehensive mass spectrometry analysis of human plasma proteome reveals tissue leakage proteins, describes variability between individual plasma proteomes and demonstrates protein transfer across the placenta during pregnancy.
    1. Cell Biology

    Comment on ‘Orthogonal lipid sensors identify transbilayer asymmetry of plasma membrane cholesterol’

    Kevin C Courtney et al.
    We challenge a recent report that most of the cholesterol in the plasma membrane of mammalian cells is in the exofacial leaflet.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Continuous transport of a small fraction of plasma membrane cholesterol to endoplasmic reticulum regulates total cellular cholesterol

    Rodney Elwood Infante, Arun Radhakrishnan
    A post-lysosomal cholesterol transport inhibitor reveals how the endoplasmic reticulum membrane regulates total cellular cholesterol by constantly monitoring a critical pool of cholesterol in the plasma membrane.
    1. Cell Biology
    2. Plant Biology

    Plant immune and growth receptors share common signalling components but localise to distinct plasma membrane nanodomains

    Christoph A Bücherl et al.
    Although genetically and biochemically linked, the plant immune and growth receptors FLS2 and BRI1 form dispersed receptor clusters within the plasma membrane that are spatiotemporally separated.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    N-chlorination mediates protective and immunomodulatory effects of oxidized human plasma proteins

    Agnes Ulfig et al.
    N-chlorination, a reversible, oxidative modification, turns plasma proteins into holdase-like chaperones, potent activators of immune cells and pro-survival factors for phagocytic immune cells.
    1. Cell Biology
    2. Neuroscience

    Pregnancy-associated plasma protein-aa supports hair cell survival by regulating mitochondrial function

    Mroj Alassaf et al.
    Hair cell survival and mitochondrial function is supported by an extracellular stimulator of IGF1 signaling, the protease pregnancy-associated plasma protein-aa.
    1. Microbiology and Infectious Disease

    A type III-A CRISPR-Cas system employs degradosome nucleases to ensure robust immunity

    Lucy Chou-Zheng, Asma Hatoum-Aslan
    Degradosome-associated nucleases PNPase and RNase J2 are required for type III CRISPR immunity against diverse nucleic acid invaders originating from plasmid and phage.
    1. Neuroscience

    Plasmon resonance and the imaging of metal-impregnated neurons with the laser scanning confocal microscope

    Karen J Thompson et al.
    A new method allows silver- and gold-labeled tissues to be imaged with confocal microscopy, avoiding the problem of fluorescence photobleaching.
    1. Epidemiology and Global Health
    2. Plant Biology

    Plant Pathology: Plasmid-powered evolutionary transitions

    Ryan A Melnyk, Cara H Haney
    The acquisition of a virulence plasmid is sufficient to turn a beneficial strain of Rhodococcus bacteria into a pathogen.
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    1. Neuroscience

    Myosin V functions as a vesicle tether at the plasma membrane to control neurotransmitter release in central synapses

    Dario Maschi et al.
    Synaptic vesicles undergo reversible tethering at the plasma membrane which is activity- and myosin V- dependent.

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