18 results found
    1. Medicine

    An herbal drug combination identified by knowledge graph alleviates the clinical symptoms of plasma cell mastitis patients: A nonrandomized controlled trial

    Caigang Liu, Hong Yu ... Yongliang Yang
    Knowledge graph identified an herbal drug combination for the treatment of plasma cell mastitis.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Plasmodium-infected erythrocytes induce secretion of IGFBP7 to form type II rosettes and escape phagocytosis

    Wenn-Chyau Lee, Bruce Russell ... Laurent Renia
    Plasmodium parasites use host-derived factors to form more rosettes and hamper phagocytosis, representing a new escape mechanism for the malaria parasites.
    1. Cancer Biology

    Revised International Staging System (R-ISS) stage-dependent analysis uncovers oncogenes and potential immunotherapeutic targets in multiple myeloma (MM)

    Ling Zhong, Peng Hao ... Bo Gong
    Among multiple myeloma stratified by Revised International Staging System, single-cell transcriptome atlas reveals novel heterogeneities with NKG7+ cytotoxic plasma cells (PCs) enriched in stage II, RRM2+ high proliferative PCs enriched in stage III, and MKI67 up-regulated in EBV-positive patients.
    1. Immunology and Inflammation

    Neonatal-derived IL-17 producing dermal γδ T cells are required to prevent spontaneous atopic dermatitis

    Nicholas A Spidale, Nidhi Malhotra ... Joonsoo Kang
    Neonatal-origin dermal Tγδ17 cells are required to maintain normal keratinocytes and prevent spontaneous atopic dermatitis.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    The chemorepellent, SLIT2, bolsters innate immunity against Staphylococcus aureus

    Vikrant K Bhosle, Chunxiang Sun ... Lisa A Robinson
    SLIT2, a prototypic neuro-repellent, spatiotemporally coordinates host defense against Staphylococcus aureus infection by priming neutrophils and stimulating release of reactive oxygen species and secondary and tertiary granules, potently enhancing bactericidal actions of neutrophils.
    1. Neuroscience

    A calibrated optogenetic toolbox of stable zebrafish opsin lines

    Paride Antinucci, Adna Dumitrescu ... Claire Wyart
    Generation of stable transgenic opsin lines together with in vivo calibration of their efficacy using behavioural and electrophysiological assays constitutes a novel optogenetic toolkit in zebrafish.
    1. Cell Biology
    2. Physics of Living Systems

    Mechanically stimulated ATP release from murine bone cells is regulated by a balance of injury and repair

    Nicholas Mikolajewicz, Elizabeth A Zimmermann ... Svetlana V Komarova
    Bone cells exposed to physiological forces release ATP through repairable membrane injury, generating an intercellular signal that conveys the destructive potential of forces and the adaptive capacity of endangered cells.
    1. Neuroscience

    Polyglycerol-opioid conjugate produces analgesia devoid of side effects

    Sara González-Rodríguez, Mohiuddin A Quadir ... Christoph Stein
    A novel opioid formulation producing analgesia similar to conventional opioids without permeation of blood-brain or intestinal barriers, thus precluding sedation, constipation and respiratory depression.
    1. Microbiology and Infectious Disease

    Kasugamycin potentiates rifampicin and limits emergence of resistance in Mycobacterium tuberculosis by specifically decreasing mycobacterial mistranslation

    Swarnava Chaudhuri, Liping Li ... Babak Javid
    Kasugamycin potentiates rifampicin killing of Mycobacterium tuberculosis by targeting adaptive mistranslation.
    1. Cancer Biology

    Single-cell dissection of prognostic architecture and immunotherapy response in Helicobacter pylori infection associated gastric cancer

    Xin Zhang, Guangyu Zhang ... Chunjie Liu
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing

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