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Notch signaling alters TLR-induced inflammation by skewing monocyte cell fate toward patrolling monocyte differentiation at the expense of macrophage cell fate.

Tumor immunogenicity is quantified with a novel method, and the resulting tumor immunogenicity score is an effective tumor-inherent biomarker for prediction of response to immune checkpoint inhibitors.

A proportion of glioblastoma with global hypo-methylation are enriched for an astrocytic signature and display increased invasion and altered immune landscape.

The tongue is a unique barrier organ, which is constantly exposed to environmental pathogens, and therefore is expected to host an immune cell network ensuring local immune defence, which we characterised during development, health, and disease.

Continuous perioperative IFNα therapy stimulates hepatic endothelial cells to build up physical vascular barrier that limits tumor cell entry into the liver and promotes long-term antitumor immunity.

Single-cell RNA-sequencing identifies the precise cellular and molecular events that occur along the sepsis timeline in the kidney, pointing to potential biomarkers and therapeutic targets.

Metabolic abnormalities in hepatocytes cause the alteration of transcriptional profile and function of immune cells in the tissue microenvironment.

Reticulon 1A plays a central role not only in cytoskeletal remodeling of resident Langerhans cells but also in their clustering upon Toll-like receptor activation in human skin, suggesting an important role in maintaining tissue homeostasis.

Maternal obesity and high-fat diet present metabolic, signaling, and epigenetic impediments to pathogen recognition in fetal innate immune cells that result in a state of immune paralysis during gestation and at birth.