Thymic macrophages are unique phagocytes with antigen-presenting abilities that comprise a Timd4+ subset of embryonic origin located in the cortex and a Cx3cr1+ subset derived from adult hematopoietic stem cells residing in the medulla.
Ingeborg Streng-Ouwehand, Nataschja I Ho ... Yvette van Kooyk
Controlled neo-glycosylation of antigens can influence intracellular routing of antigens and the nature and strength of immune response, and should therefore be considered as a major determinant in the design of vaccines against cancer and infectious diseases.
Cancer systems immunology is a highly interdisciplinary field that is advancing our ability to understand and predict the complex behavior that orchestrates the interplay between tumors and the immune system.
In the injured sciatic nerve, blood-derived monocytes and macrophages eat dying leukocytes, thereby contributing to nerve debridement and inflammation resolution, and this correlates with neuronal regeneration.
Only three Spike mutations enable murine SARS-CoV-2 infection, which is still strictly ACE2 dependent and causes a COVID-19-like disease in mice with immunopathology-driven lung damage.
Suhas Sureshchandra, Brianna M Doratt ... Ilhem Messaoudi
Maternal obesity and high-fat diet present metabolic, signaling, and epigenetic impediments to pathogen recognition in fetal innate immune cells that result in a state of immune paralysis during gestation and at birth.
Małgorzata Anna Cichoń, Karin Pfisterer ... Adelheid Elbe-Bürger
Reticulon 1A plays a central role not only in cytoskeletal remodeling of resident Langerhans cells but also in their clustering upon Toll-like receptor activation in human skin, suggesting an important role in maintaining tissue homeostasis.
Danielle Janosevic, Jered Myslinski ... Pierre C Dagher
Single-cell RNA-sequencing identifies the precise cellular and molecular events that occur along the sepsis timeline in the kidney, pointing to potential biomarkers and therapeutic targets.
