13 results found
    1. Developmental Biology
    2. Immunology and Inflammation

    Muscle function and homeostasis require cytokine inhibition of AKT activity in Drosophila

    Katrin Kierdorf et al.
    A cytokine partly derived from macrophages is required to promote normal muscle health and metabolism by inhibiting the activity of the insulin signalling pathway in the fruitfly Drosophila melanogaster.
    1. Developmental Biology

    Hematopoiesis: New ways to make a blood cell

    Ines Anderl, Dan Hultmark
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    1. Stem Cells and Regenerative Medicine
    2. Immunology and Inflammation

    Modulation of occluding junctions alters the hematopoietic niche to trigger immune activation

    Rohan J Khadilkar et al.
    Occluding-junctions form a permeability barrier around the hematopoietic niche in Drosophila that controls the production of immune cells in response to infection by shaping the signalling micro-environment produced by the niche.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Embryonic hematopoiesis modulates the inflammatory response and larval hematopoiesis in Drosophila

    Wael Bazzi et al.
    Distinct hematopoietic waves interact via transcriptional cascades specific to embryonic hemocytes to ensure the proper immune response in Drosophila.​.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Dpp dependent Hematopoietic stem cells give rise to Hh dependent blood progenitors in larval lymph gland of Drosophila

    Nidhi Sharma Dey et al.
    Identification of Hematopoietic stem cells (HSCs) in the genetically amenable organism Drosophila melanogaster paves the path to address HSC biology, both in normal and pathophysiological conditions.
    1. Stem Cells and Regenerative Medicine

    Reactive oxygen species-dependent Toll/NF-κB activation in the Drosophila hematopoietic niche confers resistance to wasp parasitism

    Isabelle Louradour et al.
    In the Drosophila hematopoietic microenvironment, a regulatory network involving Toll/NF-B, EGFR signaling and reactive oxygen species controls blood cell production in response to immune stress.
    1. Developmental Biology

    A population of adult satellite-like cells in Drosophila is maintained through a switch in RNA-isoforms

    Hadi Boukhatmi, Sarah Bray
    Adult muscle progenitors evade differentiation by expressing a short RNA isoform of Zfh1 which is insensitive to regulation by a micro-RNA.
    1. Developmental Biology

    Drosophila sessile hemocyte clusters are true hematopoietic tissues that regulate larval blood cell differentiation

    Alexandre B Leitão, Élio Sucena
    Blood cell transdifferentiation in Drosophila generates larval crystal cells through Notch-dependent signaling.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Serotonin modulates insect hemocyte phagocytosis via two different serotonin receptors

    Yi-xiang Qi et al.
    Insects use serotonin signaling in blood cells to help defend themselves against pathogens.
    1. Developmental Biology
    2. Immunology and Inflammation

    A single-cell survey of Drosophila blood

    Sudhir Gopal Tattikota et al.
    Single-cell RNA sequencing of Drosophila hemocytes in blood distinguishes various states within known blood cell types and implicates a novel role for fibroblast growth factor receptor signaling in inter-hemocyte crosstalk.

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