180 results found
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease
    Tropical disease

    Tropical Disease: A Collection of Articles

    Edited by Prabhat Jha et al.
    eLife has published papers on many tropical diseases, including malaria, Ebola, leishmaniases, Dengue and African sleeping sickness.
  1. Episode 39: Spotlight on tropical diseases

    In this special episode we discuss diseases that are common in tropical countries including tuberculosis, Zika, malaria and schistosomiasis.
    1. Genetics and Genomics
    2. Evolutionary Biology

    Current CRISPR gene drive systems are likely to be highly invasive in wild populations

    Charleston Noble et al.
    If released in the wild, current CRISPR-based gene drive systems designed to alter populations could spread much farther than intended, despite the evolution of drive resistance.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Discovery of a metabolic alternative to the classical mevalonate pathway

    Nikki Dellas et al.
    A combination of phylogenetic and biochemical analyses suggest that some unexpected variations in the synthesis of isoprenoids may be widespread across all three domains of life.
    1. Structural Biology and Molecular Biophysics

    Accelerated cryo-EM structure determination with parallelisation using GPUs in RELION-2

    Dari Kimanius et al.
    Using GPUs for the costly computations in cryo-EM enables structure determination in mere days on a single workstation.
  2. Interview: Tying everything together

    Having the freedom to follow her curiosity has enabled Yael Artzy-Randrup to explore the boundaries of ecology and evolution.
  3. Road

    Innovation Leaders 2020: Introducing the cohort

    We announce the participants and projects joining our new mentorship and open leadership training programme.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Conformational distributions of isolated myosin motor domains encode their mechanochemical properties

    Justin R Porter et al.
    Shifts in the balance between nucleotide-favorable and nucleotide-unfavorable conformations of myosin motors encode duty ratios and ADP release rates, demonstrating the power of an ensemble perspective for uncovering sequence-function relationships.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    A new protocol for single-cell RNA-seq reveals stochastic gene expression during lag phase in budding yeast

    Abbas Jariani et al.
    A new high-throughput method for single-cell RNA-seq in yeast cells shows how stochastic expression of glucose-repressed genes contributes to cell-to-cell differences during adaptation to an environmental change.

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