In-built competing effects are present at different levels in signaling networks, starting from basic biochemical building blocks to the network level, and mathematical and computational analysis reveals when they give rise to biphasic responses and what the consequences are.
An open letter signed by more than 200 eLife editors affirms the importance of open, respectful disagreements and robust discussion as pillars of eLife's scientific mission.
GABAergic interneurons coordinate synchronous muscle contractions along the length of the fruit fly larva to control the duration between peristaltic waves and locomotion speed.
Carolyn Elya, Danylo Lavrentovich ... Benjamin de Bivort
In zombie fruit flies, Entomophthora muscae-elicited summiting behavior is mediated by blood-borne factors and the host circadian-neurosecretory network.
Investigating standard lag times prior to the pandemic and identifying key methodological considerations in lag time research can guide future investigations into the impact of time to care for patients with cancer.
Matthew T Parker, Beth K Soanes ... Gordon G Simpson
High throughput sequencing of Arabidopsis mutants lacking the U6 snRNA methyltransferase FIONA1/METTL16 uncovers the role of U6 methylation in splicing signal preferences.
Nardus Mollentze, Deborah Keen ... Daniel G Streicker
The success of angiotensin-converting enzyme 2 (ACE2)-based predictions of severe acute respiratory syndrome-associated virus 2 (SARS-CoV-2) host range stems from phylogenetic correlation, allowing development of scalable models which predict susceptibility to SARS-CoV-2 and other sarbecoviruses without requiring additional ACE2 sequencing.
