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    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Signatures of transposon-mediated genome inflation, host specialization, and photoentrainment in Entomophthora muscae and allied entomophthoralean fungi

    Jason E Stajich, Brian Lovett ... Carolyn Elya
    Entomophthora muscae has one of the largest fungal genomes (1.03 Gb) owing to extensive proliferation of transposable elements.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    The genome of the Hi5 germ cell line from Trichoplusia ni, an agricultural pest and novel model for small RNA biology

    Yu Fu, Yujing Yang ... Phillip D Zamore
    The genome sequence of Trichoplusia ni enables the use of this widespread lepidopteran pest as a model for both the study of small RNA pathways and insecticide resistance.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    m6A modification of U6 snRNA modulates usage of two major classes of pre-mRNA 5’ splice site

    Matthew T Parker, Beth K Soanes ... Gordon G Simpson
    High throughput sequencing of Arabidopsis mutants lacking the U6 snRNA methyltransferase FIONA1/METTL16 uncovers the role of U6 methylation in splicing signal preferences.
    1. Stem Cells and Regenerative Medicine

    Embryonic origin of adult stem cells required for tissue homeostasis and regeneration

    Erin L Davies, Kai Lei ... Alejandro Sánchez Alvarado
    Anarchic, cycling piwi-1+ embryonic cells gives rise to neoblasts, pluripotent stemcells required for development of all organ systems during S. mediterranea embryogenesis, as well as the maintenance andregeneration of tissues during adulthood.
    1. Neuroscience

    Distinct roles of visual, parietal, and frontal motor cortices in memory-guided sensorimotor decisions

    Michael J Goard, Gerald N Pho ... Mriganka Sur
    Visual, parietal, and frontal motor cortices play distinct and necessary roles in mapping sensory features to future motor action.
    1. Structural Biology and Molecular Biophysics

    Structure of the bacterial ribosome at 2 Å resolution

    Zoe L Watson, Fred R Ward ... Jamie HD Cate
    High-resolution maps and models of the bacterial ribosome provide new chemical insights into protein synthesis, and should enable the development of robust tools for cryo-EM structure modeling and refinement.
    1. Physics of Living Systems

    Local volume concentration, packing domains, and scaling properties of chromatin

    Marcelo A Carignano, Martin Kroeger ... Igal Szleifer
    The Self Returning Excluded Volume model is the first heuristic, stochastic chromatin model that reproduce single cell and ensemble based experiments bridging nucleosome and chromosome scales.
    1. Medicine
    2. Neuroscience

    High-intensity training enhances executive function in children in a randomized, placebo-controlled trial

    David Moreau, Ian J Kirk, Karen E Waldie
    Short bursts of high-intensity exercise elicit robust improvements in core cognitive abilities, especially in individuals whose genotype is associated with lower cognitive performance.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Protein evidence of unannotated ORFs in Drosophila reveals diversity in the evolution and properties of young proteins

    Eric B Zheng, Li Zhao
    The analysis of mass-spectrometry data for all possible open reading frames reveals protein evidence for evolutionarily young, unannotated proteins with distinct characters.
    1. Neuroscience

    Synchronous multi-segmental activity between metachronal waves controls locomotion speed in Drosophila larvae

    Yingtao Liu, Eri Hasegawa ... Hiroshi Kohsaka
    GABAergic interneurons coordinate synchronous muscle contractions along the length of the fruit fly larva to control the duration between peristaltic waves and locomotion speed.