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    1. Neuroscience
    2. Medicine

    Common resting brain dynamics indicate a possible mechanism underlying zolpidem response in severe brain injury

    Shawniqua T Williams, Mary M Conte ... Nicholas D Schiff
    The therapeutic effects of the sleeping pill zolpidem in patients with disorders of consciousness may be due to recruitment of brain cells idling in abnormally low-frequency brain waves.
    1. Epidemiology and Global Health
    2. Medicine

    The impact of lag time to cancer diagnosis and treatment on clinical outcomes prior to the COVID-19 pandemic: A scoping review of systematic reviews and meta-analyses

    Parker Tope, Eliya Farah ... Eduardo L Franco
    Investigating standard lag times prior to the pandemic and identifying key methodological considerations in lag time research can guide future investigations into the impact of time to care for patients with cancer.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    MicroCT-based phenomics in the zebrafish skeleton reveals virtues of deep phenotyping in a distributed organ system

    Matthew Hur, Charlotte A Gistelinck ... Ronald Y Kwon
    Deep skeletal phenotyping in adult zebrafish reveals enhanced sensitivity of phenomic patterns in discriminating mutant populations.
    1. Neuroscience

    The visual speech head start improves perception and reduces superior temporal cortex responses to auditory speech

    Patrick J Karas, John F Magnotti ... Michael S Beauchamp
    Human perception and brain responses differ between words, in which mouth movements are visible before the voice is heard, and words, for which the reverse is true.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Protein evidence of unannotated ORFs in Drosophila reveals diversity in the evolution and properties of young proteins

    Eric B Zheng, Li Zhao
    The analysis of mass-spectrometry data for all possible open reading frames reveals protein evidence for evolutionarily young, unannotated proteins with distinct characters.
    1. Neuroscience

    Synchronous multi-segmental activity between metachronal waves controls locomotion speed in Drosophila larvae

    Yingtao Liu, Eri Hasegawa ... Hiroshi Kohsaka
    GABAergic interneurons coordinate synchronous muscle contractions along the length of the fruit fly larva to control the duration between peristaltic waves and locomotion speed.
    1. Evolutionary Biology

    Recent shifts in the genomic ancestry of Mexican Americans may alter the genetic architecture of biomedical traits

    Melissa L Spear, Alex Diaz-Papkovich ... Ryan D Hernandez
    Admixture dynamics have recently changed over time in Mexican Americans resulting in an impact on the genetic architecture of phenotypic variation.
    1. Computational and Systems Biology

    Knock-down of a regulatory barcode shifts macrophage polarization destination from M1 to M2 and increases pathogen burden upon S. aureus infection

    Sathyabaarathi Ravichandran, Bharat Bhatt ... Nagasuma Chandra
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Physics of Living Systems

    Local volume concentration, packing domains, and scaling properties of chromatin

    Marcelo A Carignano, Martin Kroeger ... Igal Szleifer
    The Self Returning Excluded Volume model is the first heuristic, stochastic chromatin model that reproduce single cell and ensemble based experiments bridging nucleosome and chromosome scales.
    1. Medicine
    2. Neuroscience

    High-intensity training enhances executive function in children in a randomized, placebo-controlled trial

    David Moreau, Ian J Kirk, Karen E Waldie
    Short bursts of high-intensity exercise elicit robust improvements in core cognitive abilities, especially in individuals whose genotype is associated with lower cognitive performance.