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    1. Chromosomes and Gene Expression

    Rapid DNA replication origin licensing protects stem cell pluripotency

    Jacob Peter Matson et al.
    The unique cell cycle variations of pluripotent stem cells ensures that the first step in DNA replication is particularly fast and this rapid rate, in turn, restrains early differentiation.
    1. Biochemistry and Chemical Biology
    2. Stem Cells and Regenerative Medicine

    SOX2 O-GlcNAcylation alters its protein-protein interactions and genomic occupancy to modulate gene expression in pluripotent cells

    Samuel A Myers et al.
    A post-translational modification called O-GlcNAcylation modulates the activity of the SOX2 transcription factor in pluripotent stem cells.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Patient-specific iPSC-derived photoreceptor precursor cells as a means to investigate retinitis pigmentosa

    Budd A Tucker et al.
    Skin cells from a patient with retinitis pigmentosa have been used to generate induced pluripotent stem cells, which could potentially form the basis of new treatments for this disease.
    1. Stem Cells and Regenerative Medicine
    2. Chromosomes and Gene Expression

    Essential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency

    Yul W Yang et al.
    RNA binding is a key input of an active chromatin complex and maintenance of stem cell fate.
    1. Stem Cells and Regenerative Medicine

    Mammalian genes induce partially reprogrammed pluripotent stem cells in non-mammalian vertebrate and invertebrate species

    Ricardo Antonio Rosselló et al.
    Cells from vertebrate and invertebrate model systems can be reprogrammed into stem-like cells using mouse genes.
    1. Human Biology and Medicine

    Stem Cells: Put to the test

    Marites T Woon, Timothy J Kamp
    Personalized heart muscle cells made from stem cells in the laboratory could be used to check an individual’s response to potential new drugs before clinical trials.
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    1. Stem Cells and Regenerative Medicine

    Organoids: Synthetic scaffolds help airway cells reach maturity

    Marko Z Nikolić, Emma L Rawlins
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    1. Stem Cells and Regenerative Medicine

    Cell Fate Choice: Ready, set, differentiate!

    Margarida Sancho, Tristan A Rodríguez
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    1. Developmental Biology
    2. Human Biology and Medicine

    CHARGE syndrome modeling using patient-iPSCs reveals defective migration of neural crest cells harboring CHD7 mutations

    Hironobu Okuno et al.
    Neural crest cells differentiated from patient-derived cells with mutations in the chromatin remodeler CHD7 show defective delamination, migration and motility in vitro, and defective migration in chick embryos.