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108 results found
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Investigating molecular crowding within nuclear pores using polarization-PALM

    Guo Fu et al.
    The super-resolution fluorescence microscopy approach polarization PALM (p-PALM) reveals that macromolecular crowding and inhomogeneity within nuclear pores generate a structurally and dynamically complex permeability barrier.
    1. Neuroscience

    A connectome of a learning and memory center in the adult Drosophila brain

    Shin-ya Takemura et al.
    Connectomic analysis in the fly's (Drosophila) learning and memory center identifies unique circuit motifs that have not been anticipated by over 30 years of extensive anatomical, experimental and theoretical studies.
    1. Neuroscience

    Distinct roles for innexin gap junctions and hemichannels in mechanosensation

    Denise S Walker, William R Schafer
    The innexin protein UNC-7, a homologue of vertebrate pannexins, plays a specific, gap junction-independent role in C. elegans mechanosensation.
    1. Neuroscience

    Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulfate production

    Magali Macchi et al.
    Heparan sulfate synthesis by mature oligodendrocytes creates a protective and permissive environment controling microglia and oligodendrocyte progenitors reactivation during remyelination.
    1. Cell Biology

    Cytokinesis in vertebrate cells initiates by contraction of an equatorial actomyosin network composed of randomly oriented filaments

    Felix Spira et al.
    Asymmetric tension increase along the cell equator promotes self-organization of actomyosin into a partially aligned network during cytokinetic cleavage furrow ingression of vertebrate cells.
    1. Neuroscience

    Feedback inhibition and its control in an insect olfactory circuit

    Subhasis Ray et al.
    Electrophysiological recordings and a large-scale biophysical model show that a unique inhibitory neuron plays a central role in structuring olfactory codes in the insect brain.
    1. Immunology and Inflammation

    Pivotal role for skin transendothelial radio-resistant anti-inflammatory macrophages in tissue repair

    Olga Barreiro et al.
    A new type of skin perivascular macrophages with extramedullary origin, access to blood and exclusive anti-inflammatory reparative properties has been characterized.
    1. Cell Biology

    Scaffold-mediated gating of Cdc42 signalling flux

    Péter Rapali et al.
    The scaffold Bem1 increases the rate of GEF-mediated Cdc42 activation, while also increasing the rate and extent of GEF phosphorylation by PAK, which attenuates further scaffold stimulation.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Modularity and determinants of a (bi-)polarization control system from free-living and obligate intracellular bacteria

    Matthieu Bergé et al.
    Common ancestries, activities and structural determinants of a modular (bi-)polarization control system encoded in free-living and obligate intracellular α-proteobacteria, including the rickettsial pathogens, are described.
    1. Neuroscience

    State-dependent cell-type-specific membrane potential dynamics and unitary synaptic inputs in awake mice

    Aurélie Pala, Carl CH Petersen
    Membrane potential recordings in awake mice from two genetically defined classes of neocortical inhibitory neurons reveal their distinct patterns of activity and unitary excitatory synaptic inputs, which are differentially modulated by behavior and local network activity.

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