893 results found
    1. Developmental Biology

    Hippo signaling determines the number of venous pole cells that originate from the anterior lateral plate mesoderm in zebrafish

    Hajime Fukui, Takahiro Miyazaki ... Naoki Mochizuki
    The Hippo signaling restricts the number of SHF cardiomyocytes in the venous pole by negatively regulating Bmp-Smad signaling in the cells of lateral plate mesoderm.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    A conserved cell-pole determinant organizes proper polar flagellum formation

    Erick E Arroyo-Pérez, John C Hook ... Simon Ringgaard
    FipA is a novel component required for bacteria that rely on FlhF/FlhG to properly localize their flagella to the cell pole.
    1. Microbiology and Infectious Disease

    The alternative sigma factor σX mediates competence shut-off at the cell pole in Streptococcus pneumoniae

    Calum HG Johnston, Anne-Lise Soulet ... Patrice Polard
    Tracking fluorescent fusion proteins in competent pneumococcal cells reveals a polar hub for competence regulation, with the alternative sigma factor σX relocalizing DprA to this hub to mediate competence shut-off.
    1. Physics of Living Systems

    How to assemble a scale-invariant gradient

    Arnab Datta, Sagnik Ghosh, Jane Kondev
    Intracellular protein gradients, which are formed by the combined action of cytoplasmic diffusion and cortical transport toward the cell pole, are solely determined by cell shape.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Structured illumination with particle averaging reveals novel roles for yeast centrosome components during duplication

    Shannon Burns, Jennifer S Avena ... Sue L Jaspersen
    Visualization of yeast spindle pole proteins using a new microscopy method shows that assembly into the nuclear membrane occurs at the same time as duplication.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Polo-like kinase Cdc5 regulates Spc72 recruitment to spindle pole body in the methylotrophic yeast Ogataea polymorpha

    Hiromi Maekawa, Annett Neuner ... Yoshinobu Kaneko
    Cdc5-dependent SPB regulation is linked to delayed cytoplasmic microtubule organization in Ogataea polymorpha.
    1. Microbiology and infectious disease

    Asymmetric division triggers cell-specific gene expression through coupled capture and stabilization of a phosphatase

    Niels Bradshaw, Richard Losick
    Asymmetric cell division is linked to cell-specific transcription by handoff of a key developmental regulator from the cytokinetic machinery to the adjacent cell pole where it oligomerizes to become stabilized and activated.
    1. Cell Biology
    2. Physics of Living Systems

    Three-dimensional structure of kinetochore-fibers in human mitotic spindles

    Robert Kiewisz, Gunar Fabig ... Thomas Müller-Reichert
    Comprehensive 3D electron tomography reconstructions of metaphase spindles in human tissue culture cells reveal that kinetochore-fibers broaden as they extend polewards, forming semi-direct connections to the pole, where they preferentially interact with the spindle network.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Coupling chemosensory array formation and localization

    Alejandra Alvarado, Andreas Kjær ... Simon Ringgaard
    Formation and cell pole-localization of chemotactic signaling-arrays is a coupled process mediated by ParP, which drives localized array-assembly and regulates the localization-dynamics of its network constituents.
    1. Plant Biology

    Phloem unloading in Arabidopsis roots is convective and regulated by the phloem-pole pericycle

    Timothy J Ross-Elliott, Kaare H Jensen ... Karl J Oparka
    A study of solute and macromolecule trafficking in plants reveals a previously undescribed route for carbon distribution in growing root tissues.

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