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    1. Microbiology and Infectious Disease

    Thermosynechococcus switches the direction of phototaxis by a c-di-GMP-dependent process with high spatial resolution

    Daisuke Nakane, Gen Enomoto ... Takayuki Nishizaka
    Colour-controlled c-di-GMP signalling mediates directional switch of phototaxis via within-a-pole regulation of type IV pili in rod-shaped cyanobacteria Thermosynechococcus vulcanus.
    1. Developmental Biology

    Antagonism between germ cell-less and Torso receptor regulates transcriptional quiescence underlying germline/soma distinction

    Megan M Colonnetta, Lauren R Lym ... Girish Deshpande
    A molecular duel between germline and somatic determinants ensures proper establishment of transcriptional quiescence in the primordial germ cells of early Drosophila embryos.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Peptidoglycan precursor synthesis along the sidewall of pole-growing mycobacteria

    Alam García-Heredia, Amol Arunrao Pohane ... M Sloan Siegrist
    Peptidoglycan precursor synthesis occurs in both growing and non-growing regions of the mycobacterial cell surface.
    1. Cell Biology

    Orderly assembly underpinning built-in asymmetry in the yeast centrosome duplication cycle requires cyclin-dependent kinase

    Marco Geymonat, Qiuran Peng ... Marisa Segal
    The polarized orientation of the mitotic spindle in budding yeast arises from spindle pole structural and functional asymmetry subject to cell cycle control.
    1. Cell Biology
    2. Physics of Living Systems

    Self-organization of kinetochore-fibers in human mitotic spindles

    William Conway, Robert Kiewisz ... Daniel J Needleman
    A biophysical model in which kinetochore microtubules nucleate at kinetochores and growth polward along nematic streamlines quantitatively explains kinetochore microtubule lengths, orientations, and spatially varying dynamics in metaphase human spindles.
    1. Developmental Biology
    2. Genetics and Genomics

    Caspar specifies primordial germ cell count and identity in Drosophila melanogaster

    Subhradip Das, Sushmitha Hegde ... Girish S Ratnaparkhi
    During Drosophila primordial germ cells (PGCs) specification, the centrosome and germplasm are subject to regulation, during the maternal zygotic transition, by Caspar/TER94-dependent degradative pathways that influence PGC determinants.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A mitotic kinase scaffold depleted in testicular seminomas impacts spindle orientation in germ line stem cells

    Heidi Hehnly, David Canton ... John D Scott
    A protein kinase complex that is important for cell division is lost in testicular seminoma, which is a common cancer in men.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Germline/soma distinction in Drosophila embryos requires regulators of zygotic genome activation

    Megan M Colonnetta, Paul Schedl, Girish Deshpande
    Components of zygotic genome activation, Zelda and CLAMP, contribute to the proper specification of primordial germ cells in Drosophila embryos.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Assembly and positioning of actomyosin rings by contractility and planar cell polarity

    Ivonne M Sehring, Pierre Recho ... Di Jiang
    Contractility wins over the polarity pathway in a tug-of-war to position a cytokinesis-like actomyosin ring at the equator of notochord cells.
    1. Stem Cells and Regenerative Medicine

    AIRE is a critical spindle-associated protein in embryonic stem cells

    Bin Gu, Jean-Philippe Lambert ... Janet Rossant
    AIRE played novel roles in the mitosis process in embryonic stem cells and early embryo cells.