10,916 results found
    1. Cancer Biology

    The chemokine CXCL13 in lung cancers associated with environmental polycyclic aromatic hydrocarbons pollution

    Gui-Zhen Wang, Xin Cheng ... Guang-Biao Zhou
    The chemokine CXCL13 is critical to the development of air pollution- and tobacco smoke-induced lung cancers.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Pollution: Transgenic pigs to the rescue

    Björn Petersen
    Genetically engineered pigs that digest their food better could help to reduce phosphorus and nitrogen pollution.
    Version of Record
    Insight
    1. Structural Biology and Molecular Biophysics

    Functional roles of Mg2+ binding sites in ion-dependent gating of a Mg2+ channel, MgtE, revealed by solution NMR

    Tatsuro Maruyama, Shunsuke Imai ... Masanori Osawa
    Nuclear magnetic resonance analysis revealed the structural and dynamical changes in MgtE during the channel closure caused by the cooperative Mg2+-binding, which had remained undescribed only by a static crystal structure.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The Peptidisc, a simple method for stabilizing membrane proteins in detergent-free solution

    Michael Luke Carlson, John William Young ... Franck Duong
    A simple, yet elegant method for robust self-assembly of diverse membrane proteins into soluble peptide nanoparticles for their structural and functional analysis in detergent-free solutions.
    1. Computational and Systems Biology
    2. Neuroscience

    Mouse brain transcriptome responses to inhaled nanoparticulate matter differed by sex and APOE in Nrf2-Nfkb interactions

    Amin Haghani, Mafalda Cacciottolo ... Caleb E Finch
    Transcriptome analysis of mouse brain revealed that the APOE4 allele and sex can alter air pollution neurotoxicity in adults.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Visualizing conformational dynamics of proteins in solution and at the cell membrane

    Sharona E Gordon, Mika Munari, William N Zagotta
    ACCuRET is a flexible new method for measuring the structural dynamics of proteins in solution and membrane proteins in their native environment.
    1. Cancer Biology

    Proteogenomic analysis of air-pollution-associated lung cancer reveals prevention and therapeutic opportunities

    Honglei Zhang, Chao Liu ... Gaofeng Li
    MAD1 and TPRN were identified as novel potential therapeutic targets of lung adenocarcinoma in female never-smokers from the Xuanwei area.
    1. Structural Biology and Molecular Biophysics

    The Candida albicans virulence factor candidalysin polymerizes in solution to form membrane pores and damage epithelial cells

    Charles M Russell, Katherine G Schaefer ... Francisco N Barrera
    The molecular mechanism that candidalysin uses to perforate membranes is unraveled, which opens the door to the rational design of inhibitors against candidiasis.
    1. Structural Biology and Molecular Biophysics

    Structure and physiological function of the human KCNQ1 channel voltage sensor intermediate state

    Keenan C Taylor, Po Wei Kang ... Charles R Sanders
    The intermediate state conformation of the human KCNQ1 potassium channel voltage sensor domain was determined, validated, and shown to be conductive under physiological conditions.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Substrate specificity of TOR complex 2 is determined by a ubiquitin-fold domain of the Sin1 subunit

    Hisashi Tatebe, Shinichi Murayama ... Kazuhiro Shiozaki
    Sin1, a regulatory subunit of TOR protein kinase, has an evolutionarily conserved domain that specifically binds and recruits substrate for phosphorylation, and may represent a potential target for anti-cancer drugs.

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