2,467 results found
    1. Cell Biology

    Polo-like kinase 1 induces epithelial-to-mesenchymal transition and promotes epithelial cell motility by activating CRAF/ERK signaling

    Jianguo Wu et al.
    Overexpression of PLK1 triggers oncogenic transformation and transcriptional reprogramming of prostate epithelial cells, which stimulates cell migration and invasion.
    1. Cell Biology

    PLK-1 promotes the merger of the parental genome into a single nucleus by triggering lamina disassembly

    Griselda Velez-Aguilera et al.
    The polo-like kinase (Plk1) phophorylates the C. elegans lamin LMN-1 to promote timely lamina disassembly, which is essential for the merging of the parental chromosomes at the beginning of life.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    A requirement of Polo-like kinase 1 in murine embryonic myogenesis and adult muscle regeneration

    Zhihao Jia et al.
    Inhibition of Polo-like kinase that has been shown to exhibit antitumor effect unexpectedly disrupts muscle stem cell function, leading to developmental and regenerative failures.
  1. Point of View: Overflow in science and its implications for trust

    Sabina Siebert et al.
    Interviews with senior biomedical researchers reveal a perceived decline in trust in the scientific enterprise, in large part because the quantity of new data exceeds the field's ability to process it appropriately.
    1. Microbiology and Infectious Disease

    Research: A comprehensive and quantitative exploration of thousands of viral genomes

    Gita Mahmoudabadi, Rob Phillips
    A compendium of critical genomic numbers for viruses through the lenses of different viral classification systems.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Mitosis: Checkpoint proteins come under scrutiny

    Maria Mora-Santos, Jonathan BA Millar
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    1. Evolutionary Biology
    Baboon illustration

    The Natural History of Model Organisms: Insights into the evolution of social systems and species from baboon studies

    Julia Fischer et al.
    Wild baboons are an excellent model to study complex evolutionary processes such as speciation and hybridization, as well as the links between sociality, longevity and reproductive success.
    1. Cell Biology

    Cell Division: How centrioles acquire the ability to reproduce

    Midori Ohta et al.
    A protein called SAS-7 is required for daughter centrioles to become mothers in C. elegans.
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    1. Cell Biology

    Cell Biology: A new regulator of caveolae signalling

    Alan J Whitmarsh
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    1. Medicine
    2. Neuroscience

    Point of View: Coordinating a new approach to basic research into Parkinson’s disease

    Randy Schekman, Ekemini AU Riley
    The ASAP initiative will incentivize collaboration between researchers and encourage open-science practices to improve our understanding of the biology underlying Parkinson's disease.

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