41 results found
    1. Neuroscience

    Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription

    Rui Gao et al.
    Polyglutamine expansion in mutant huntingtin disrupts a novel transcription-coupled DNA repair complex, providing an undescribed mechanism of neuronal toxicity and degeneration in Huntington's disease.
    1. Neuroscience

    Nemo-like kinase is a novel regulator of spinal and bulbar muscular atrophy

    Tiffany W Todd et al.
    Nemo-like kinase is a key protein promoting the pathogenesis of spinal and bulbar muscular atrophy.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Interferon-β-induced miR-1 alleviates toxic protein accumulation by controlling autophagy

    Camilla Nehammer et al.
    A microRNA prevents the accumulation of toxic proteins by inducing autophagy.
    1. Cell Biology

    Spatial sequestration and detoxification of Huntingtin by the ribosome quality control complex

    Junsheng Yang et al.
    A genome-wide screen in yeast reveals that key proteins in ribosome quality control also regulate mutant Huntingtin aggregation and toxicity.
    1. Cell Biology
    2. Neuroscience

    Presynaptic APP levels and synaptic homeostasis are regulated by Akt phosphorylation of huntingtin

    Julie Bruyère et al.
    Reducing Akt-mediated huntingtin phosphorylation decreases APP accumulation at the synapse by reducing its anterograde axonal transport and ameliorates learning and memory in a mouse model of familial Alzheimer disease.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Proteome-wide signatures of function in highly diverged intrinsically disordered regions

    Taraneh Zarin et al.
    Widespread, rapidly evolving disordered regions contain molecular features that are preserved over evolution and are associated with specific biological functions.
    1. Neuroscience

    Modulation of dopamine D1 receptors via histamine H3 receptors is a novel therapeutic target for Huntington's disease

    David Moreno-Delgado et al.
    Progression of Huntington's disease can be slowed by altering dopamine signalling through the Dopamine 1 receptor - Histamine 3 receptor heteromer.
    1. Cell Biology

    Stress-induced Cdk5 activity enhances cytoprotective basal autophagy in Drosophila melanogaster by phosphorylating acinus at serine437

    Nilay Nandi et al.
    Cdk5-mediated stabilization of Acinus in postmitotic neurons promotes autophagy and the removal of protein aggregates linked to neurodegeneration in Drosophila melanogaster.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Pi-Pi contacts are an overlooked protein feature relevant to phase separation

    Robert McCoy Vernon et al.
    Statistics on the frequencies of pi interactions in folded protein structures enable successful prediction of intrinsically disordered protein phase separation, with clear implications for a physical understanding of cellular organization.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Atrophin controls developmental signaling pathways via interactions with Trithorax-like

    Kelvin Yeung et al.
    ChIP-seq and phenotypic analyses reveal Atrophin from Drosophila directly regulates Notch and Dpp signaling components, and engrailed gene expression, via interactions with GAGA Factor.

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