411 results found
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Polymerase θ is a robust terminal transferase that oscillates between three different mechanisms during end-joining

    Tatiana Kent et al.
    Polymerase θ is among the most proficient terminal transferases known and switches between three different mechanisms of terminal transferase activity.
    1. Biochemistry and Chemical Biology

    Characterization of human translesion DNA synthesis across a UV-induced DNA lesion

    Mark Hedglin et al.
    Quantitative binding and kinetic assays on DNA polymerases η and δ define the mechanism for polymerase exchange during human translesion DNA synthesis across a UV-induced lesion on the lagging strand.
    1. Microbiology and Infectious Disease

    pp32 and APRIL are host cell-derived regulators of influenza virus RNA synthesis from cRNA

    Kenji Sugiyama et al.
    The host-derived factors, pp32 and APRIL, interact with influenza viral RNA polymerase to support viral genomic RNA synthesis from complementary RNA.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Mechanism for priming DNA synthesis by yeast DNA Polymerase α

    Rajika L Perera et al.
    The details of how the enzyme DNA polymerase α initiates the polymerization of nucleotides in DNA replication, a critical step in the synthesis of new chromosomal DNA, have been revealed in atomic detail.
    1. Chromosomes and Gene Expression

    Factors affecting template switch recombination associated with restarted DNA replication

    Manisha Jalan et al.
    Genomic deletions and gene conversions, caused by template switching associated with restarted DNA replication, are detected downstream of a collapsed replication fork and are suppressed by several conserved DNA helicases.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Investigating the trade-off between folding and function in a multidomain Y-family DNA polymerase

    Xiakun Chu et al.
    The physical interaction network encoded in the multi-domain protein native structure handles the trade-off between the fast, stable folding and the efficient, reliable function.
    1. Physics of Living Systems

    A mechanism for hunchback promoters to readout morphogenetic positional information in less than a minute

    Jonathan Desponds et al.
    Maternal positional information in the fly embryo can be read rapidly in spite of the gene-expression bottleneck and general examples of regulatory architectures that combine speed and accuracy are provided.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Expression site attenuation mechanistically links antigenic variation and development in Trypanosoma brucei

    Christopher Batram et al.
    The VSG gene controls its monoallelic expression, and expression site activity determines developmental progression.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Single-molecule studies contrast ordered DNA replication with stochastic translesion synthesis

    Gengjing Zhao et al.
    Competing DNA polymerases at the DNA sliding clamp are revealed by single-molecule co-localization studies.
    1. Biochemistry and Chemical Biology

    Random-sequence genetic oligomer pools display an innate potential for ligation and recombination

    Hannes Mutschler et al.
    Random sequence RNA pools display an innate capacity for ligation and recombination, enabling them to “bootstrap” themselves towards higher compositional, informational and structural complexity.

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