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    1. Microbiology and Infectious Disease

    Infectious polymorphic toxins delivered by outer membrane exchange discriminate kin in myxobacteria

    Christopher N Vassallo, Pengbo Cao ... Daniel Wall
    Serial cell-to-cell transfer of lipoprotein toxins by outer membrane exchange provides a potent platform for kin discrimination in Myxococcus xanthus.
    1. Cell Biology
    2. Evolutionary Biology

    Genetic diversity of CHC22 clathrin impacts its function in glucose metabolism

    Matteo Fumagalli, Stephane M Camus ... Frances M Brodsky
    Natural selection shaped CHC22 clathrin genetic variation in humans with different diets and potentially influenced the human insulin response.
    1. Evolutionary Biology

    Evolution of novel mimicry polymorphisms through Haldane’s sieve and rare recombination

    Riddhi Deshmukh, Saurav Baral ... Krushnamegh Kunte
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Evolutionary Biology
    2. Genetics and Genomics

    Joint inference of evolutionary transitions to self-fertilization and demographic history using whole-genome sequences

    Stefan Strütt, Thibaut Sellinger ... Stefan Laurent
    Transitions from outcrossing to selfing, a major shift in mating systems, create a specific signature in intra-specific genetic polymorphisms, which can be used to infer the demographic history of populations and acquire valuable insights about the evolution of recombination rates.
    1. Evolutionary Biology

    The genetic architecture of the load linked to dominant and recessive self-incompatibility alleles in Arabidopsis halleri and Arabidopsis lyrata

    Audrey Le Veve, Mathieu Genete ... Vincent Castric
    By modulating the intensity of balancing selection at the S-locus, dominance between self-incompatibility alleles shapes the genetic load linked to each allele, creating inbreeding depression in some S-locus homozygotes.
    1. Evolutionary Biology
    2. Genetics and Genomics

    A population-level invasion by transposable elements triggers genome expansion in a fungal pathogen

    Ursula Oggenfuss, Thomas Badet ... Daniel Croll
    The activation of transposable elements and relaxed purifying selection underpin an incipient expansion of the genome in populations of a major wheat pathogen.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control

    István Bartha, Jonathan M Carlson ... Jacques Fellay
    An innovative strategy in genome analysis has generated a detailed description of how pathogens mutate when facing human genetic diversity.
    1. Plant Biology
    2. Structural Biology and Molecular Biophysics

    Vicia faba SV channel VfTPC1 is a hyperexcitable variant of plant vacuole Two Pore Channels

    Jinping Lu, Ingo Dreyer ... Rainer Hedrich
    Polymorphic residues of a vacuolar Ca2+ sensor site in TPC1 channels differ between species of Brassicacea and Fabaceae and lead to distinct TPC1 gating behavior.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Mutation saturation for fitness effects at human CpG sites

    Ipsita Agarwal, Molly Przeworski
    Methylated CpG sites are saturated for T mutations in a sample of 390K human exomes, providing a test case for inferences about fitness effects in human genes, and insight into the interpretation of mutations as pathogenic using reference datasets.
    1. Genetics and Genomics

    Non-allelic gene conversion enables rapid evolutionary change at multiple regulatory sites encoded by transposable elements

    Christopher E Ellison, Doris Bachtrog
    Fully functional regulatory elements can arise rapidly from transposable elements via a novel route where non-allelic gene conversion can act to speed up the evolutionary fine-tuning of regulatory elements.