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    1. Cell Biology

    Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity

    Kasparas Petkevicius et al.
    Obesity leads to increased phosphatidylcholine turnover in adipose tissue macrophages that makes them susceptible to saturated fatty acid-induced inflammation.
    1. Biochemistry and Chemical Biology

    Fatty acid remodeling by LPCAT3 enriches arachidonate in phospholipid membranes and regulates triglyceride transport

    Tomomi Hashidate-Yoshida et al.
    LPCAT3 incorporates arachidonic acid into membrane phospholipids, which promotes lipoprotein assembly by enabling triacylgylcerols to cluster in the membrane.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Acyl chain asymmetry and polyunsaturation of brain phospholipids facilitate membrane vesiculation without leakage

    Marco M Manni et al.
    The asymmetric combination of saturated and polyunsaturated acyl chains in phospholipids as typically observed in synapses makes membranes prone to deformation and fission without compromising their impermeability.
    1. Medicine

    Weight loss, insulin resistance, and study design confound results in a meta-analysis of animal models of fatty liver

    Harriet Hunter et al.
    Animal studies of fatty liver disease over-estimate the benefit of drugs due to publication bias and are confounded by off-target weight loss, illustrating the challenge of successful translational across species.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mechanistic insights into volatile anesthetic modulation of K2P channels

    Aboubacar Wague et al.
    The volatile anesthetic isoflurane directly binds to the transmembrane domains of the TREK1 channel to allosterically modulate its function.
    1. Biochemistry and Chemical Biology

    Optical manipulation of sphingolipid biosynthesis using photoswitchable ceramides

    Matthijs Kol et al.
    Photoswitchable ceramides containing an azobenzene photoswitch behave as light-controllable substrates for both sphingomyelin synthase and glucosylceramide synthase.
    1. Plant Biology

    Point of View: Europe’s first and last field trial of gene-edited plants?

    Jean-Denis Faure, Johnathan A Napier
    The reclassification of gene editing as "GM" will impact on European plant sciences, making it more difficult to validate new traits in field trials and drive forward innovation.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Membrane characteristics tune activities of endosomal and autophagic human VPS34 complexes

    Yohei Ohashi et al.
    The lipid kinase VPS34 complexes I and II are both activated by unsaturation of substrate and non-substrate lipids, curvature, electrostatics and polyphosphoinositides, which play roles in localisation and cellular function.
    1. Structural Biology and Molecular Biophysics

    Direct binding of phosphatidylglycerol at specific sites modulates desensitization of a ligand-gated ion channel

    Ailing Tong et al.
    Phosphatidylglycerol binding at multiple sites stabilizes the open state relative to the desensitized state of a pentameric ligand-gated ion channel.
    1. Evolutionary Biology

    Expansion of the fatty acyl reductase gene family shaped pheromone communication in Hymenoptera

    Michal Tupec et al.
    A fatty acyl reductase gene family expansion in the Hymenoptera crown group led to recruitment of novel pheromone-biosynthetic enzymes and is linked to evolution of pheromone marking behavior.