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    1. Evolutionary Biology

    The population genetics of convergent adaptation in maize and teosinte is not locally restricted

    Silas Tittes, Anne Lorant ... Jeffrey Ross-Ibarra
    Adaptation of domesticated maize and its wild relative teosinte has been facilitated by the geographically widespread exchange of beneficial alleles between them.
    1. Microbiology and Infectious Disease

    Quantification of Salmonella enterica serovar Typhimurium population dynamics in murine infection using a highly diverse barcoded library

    Julia A Hotinger, Ian W Campbell ... Matthew K Waldor
    Microbial lineage tracing during murine systemic infection with Salmonella uncovered the bottlenecks that restrict colonization and the hidden routes of interorgan dissemination that drive heterogeneity in infection outcomes.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Enalapril mitigates aging by targeting antioxidative genes via phosphorylated Smad1/5/9

    Wencong Lyu, Haochen Wang ... Wei Tao
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Brain areas for reversible symbolic reference, a potential singularity of the human brain

    Timo van Kerkoerle, Louise Pape ... Ghislaine Dehaene-Lambertz
    Humans spontaneously reverse learned associations while macaque monkeys do not, providing a minimal test of a distinctive human capacity for symbolic representations.
    1. Cell Biology

    Pharmacologic activation of integrated stress response kinases inhibits pathologic mitochondrial fragmentation

    Kelsey R Baron, Samantha Oviedo ... R Luke Wiseman
    Compounds that activate integrated stress response kinases inhibit mitochondrial fragmentation induced by chemical or genetic insults, indicating that targeting this pathway offers opportunities to mitigate mitochondrial fragmentation in diverse diseases.
    1. Neuroscience

    GPRC6A as a novel kokumi receptor responsible for enhanced taste preferences by ornithine

    Takashi Yamamoto, Kayoko Ueji ... Shinya Ugawa
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Cell Biology

    Oversized cells activate global proteasome-mediated protein degradation to maintain cell size homeostasis

    Shixuan Liu, Ceryl Tan ... Ran Kafri
    Oversized mammalian cells reduce their growth efficiency by activating global protein degradation, which functions in parallel with the cell size checkpoints, to promote cell size homeostasis.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome

    Kira A Cozzolino, Lynn Sanford ... Dylan J Taatjes
    The Mediator-associated kinases CDK8 and CDK19 help drive inflammatory responses to interferon, and it is discovered that kinase-dependent transcriptional responses manifest in part through splicing changes and lipid metabolites.
    1. Genetics and Genomics

    Maturation and detoxification of synphilin-1 inclusion bodies regulated by sphingolipids

    Xiuling Cao, Xiang Wu ... Beidong Liu
    Membrane lipids are involved in the maturation and cytotoxicity of Parkinson's synphilin-1 inclusion bodies.
    1. Developmental Biology

    A-to-I RNA editing of CYP18A1 mediates transgenerational wing dimorphism in aphids

    Bin Zhu, Rui Wei ... Pei Liang
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid