Browse the search results

Page 2 of 509
    1. Microbiology and Infectious Disease

    Genetic and chemical validation of Plasmodium falciparum aminopeptidase PfA-M17 as a drug target in the hemoglobin digestion pathway

    Rebecca CS Edgar, Ghizal Siddiqui ... Tania F de Koning-Ward
    Plasmodium falciparum aminopeptidase PfA-M17 is essential to parasite survival and plays a role in hemoglobin digestion, providing a rationale for further development of inhibitors against this enzyme.
    1. Physics of Living Systems

    Unrestrained growth of correctly oriented microtubules instructs axonal microtubule orientation

    Maximilian AH Jakobs, Assaf Zemel, Kristian Franze
    Biased growth of microtubules in the advancing axon tip contributes to the uniform orientation of microtubules in mature axons, which is essential for proper neuronal functioning.
    1. Computational and Systems Biology
    2. Developmental Biology

    Discovering sparse transcription factor codes for cell states and state transitions during development

    Leon A Furchtgott, Samuel Melton ... Sharad Ramanathan
    Sparse patterns in gene expression allow simultaneous discovery of cell states, lineage relationships and key genes controlling developmental decisions.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Expansion and loss of sperm nuclear basic protein genes in Drosophila correspond with genetic conflicts between sex chromosomes

    Ching-Ho Chang, Isabel Mejia Natividad, Harmit S Malik
    Genetic conflicts between sex chromosomes during spermatogenesis may drive the rapid evolution, function, and turnover of some sperm nuclear basic proteins in Drosophila species.
    1. Genetics and Genomics

    Establishment of H3K9me3-dependent heterochromatin during embryogenesis in Drosophila miranda

    Kevin H-C Wei, Carolus Chan, Doris Bachtrog
    Heterochromatin is established at nucleation sites associated with open chromatin and RNA transcripts and matures into stable domains if they are found near transposable elements targeted by maternally deposited piRNAs.
    1. Cell Biology

    Src activates retrograde membrane traffic through phosphorylation of GBF1

    Joanne Chia, Shyi-Chyi Wang ... Frederic A Bard
    Src phosphorylates GBF1, promoting binding of the Sec7 domain to Arf1 and the formation of GALNTs containing tubules emanating from the Golgi.
    1. Neuroscience

    Anterior insular cortex plays a critical role in interoceptive attention

    Xingchao Wang, Qiong Wu ... Jin Fan
    Anterior insular cortex activity predicts how well we attend to our bodily signals, while lesions to this brain region disrupt this ability.
    1. Developmental Biology
    2. Plant Biology

    Organ geometry channels reproductive cell fate in the Arabidopsis ovule primordium

    Elvira Hernandez-Lagana, Gabriella Mosca ... Célia Baroux
    In the Arabidopsis ovule primordium, germinal fate plasticity is coupled to the morphogenetic processes shaping the organ.
    1. Neuroscience

    Drosulfakinin signaling encodes early-life memory for adaptive social plasticity

    Jiwon Jeong, Kujin Kwon ... Chunghun Lim
    Social clustering behaviors in Drosophila are closely tied to compensatory mechanisms for developmental traits and adaptive behavior plasticity, requiring early-life social experiences and the memory-encoding neuropeptide signaling pathway.
    1. Neuroscience

    Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment

    Hideo Hagihara, Hirotaka Shoji ... Tsuyoshi Miyakawa
    Brain lactate and pH changes, identified as common features in diverse neuropsychiatric animal models, may represent transdiagnostic endophenotypes associated with cognitive impairment.