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    1. Ecology
    2. Genetics and Genomics

    Environmental DNA from archived leaves reveals widespread temporal turnover and biotic homogenization in forest arthropod communities

    Henrik Krehenwinkel, Sven Weber ... Michael Veith
    Environmental DNA from highly standardized leaf sample time series suggests no localized species losses, but biotic turnover and homogenization, as main drivers of forest insect decline.
    1. Evolutionary Biology

    Rapid decline of bacterial drug-resistance in an antibiotic-free environment through phenotypic reversion

    Anett Dunai, Réka Spohn ... Csaba Pál
    Drug-resistance declines in the laboratory in an antibiotic stress-free environment, indicating that restricting antimicrobial usage in the clinics could be a useful policy.
    1. Evolutionary Biology

    Can Hamilton’s rule be violated?

    Matthijs van Veelen
    Hamilton's rule can be violated when costs and benefits of cooperation are defined using the counterfactual method, and when they depend on the cooperation of others.
    1. Epidemiology and Global Health

    Relationship between changing malaria burden and low birth weight in sub-Saharan Africa: A difference-in-differences study via a pair-of-pairs approach

    Siyu Heng, Wendy P O'Meara ... Dylan S Small
    A novel pair-of-pairs matching approach finds that community-level reductions in malaria burden can potentially substantially reduce the low birth weight rate in sub-Saharan Africa, particularly among firstborns.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Towards a unified model of naive T cell dynamics across the lifespan

    Sanket Rane, Thea Hogan ... Andrew J Yates
    Naive CD4 and CD8 T cells in mice increase their survival capacity with age, but their numbers are not homeostatically regulated.
    1. Epidemiology and Global Health
    2. Evolutionary Biology

    A transmission-virulence evolutionary trade-off explains attenuation of HIV-1 in Uganda

    François Blanquart, Mary Kate Grabowski ... Christophe Fraser
    Analysis of epidemiological data reveals that viral loads in newly HIV-1 infected individuals in Uganda have declined for two decades, and evolutionary modelling shows that attenuation of the virus explains this decline.
    1. Epidemiology and Global Health
    2. Evolutionary Biology

    Estimating the potential to prevent locally acquired HIV infections in a UNAIDS Fast-Track City, Amsterdam

    Alexandra Blenkinsop, Mélodie Monod ... Oliver Ratmann
    Phylogenetic evidence suggests that the majority of HIV infections occurring in the UNAIDS Fast-track city Amsterdam continue to have an Amsterdam resident as source, indicating that the majority of HIV infections in Amsterdam could be prevented through city-level interventions.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Environment determines evolutionary trajectory in a constrained phenotypic space

    David T Fraebel, Harry Mickalide ... Seppe Kuehn
    Experimental evolution shows that when selection acts on two traits constrained by a trade-off, the direction of phenotypic evolution depends on the environment.
    1. Ecology

    A fitness trade-off between seasons causes multigenerational cycles in phenotype and population size

    Gustavo S Betini, Andrew G McAdam ... D Ryan Norris
    Seasonal variation in resources causes opposing episodes of selection on body size, which interact with density dependence to influence population dynamics.
    1. Stem Cells and Regenerative Medicine

    Rejuvenating aged osteoprogenitors for bone repair

    Joshua Reeves, Pierre Tournier ... Shukry J Habib
    Short-term interventions, including intermittent fasting, boosting cellular energy, and promoting beneficial gut bacteria, rejuvenate osteoprogenitors in aged animals and, when combined with localized Wnt, restore youthful bone healing.