5,851 results found
    1. Evolutionary Biology

    Whole genome phylogenies reflect the distributions of recombination rates for many bacterial species

    Thomas Sakoparnig et al.
    For many bacterial species, recombination dominates genome evolution and phylogenetic patterns that have so far been assumed to reflect clonal relationships, in fact reflect variation in recombination rates across lineages.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Modulation of the Erwinia ligand-gated ion channel (ELIC) and the 5-HT3 receptor via a common vestibule site

    Marijke Brams et al.
    Development of nanobodies against a model pentameric ligand-gated ion channel demonstrates they can be functionally active as negative or positive allosteric modulators and offers opportunities for future drug development.
    1. Neuroscience

    Statistical structure of locomotion and its modulation by odors

    Liangyu Tao et al.
    A fly's locomotion can be decomposed into a small number of locomotor features which can be modulated by odors and other sensory information.
    1. Microbiology and Infectious Disease

    Population structuring of multi-copy, antigen-encoding genes in Plasmodium falciparum

    Yael Artzy-Randrup et al.
    Mathematical modeling shows that local populations of the malaria parasite self-organize into a limited number of transient but distinct strains through competition for hosts in immunity space.
    1. Structural Biology and Molecular Biophysics

    Structural basis for pharmacological modulation of the TRPC6 channel

    Yonghong Bai et al.
    Novel drug-binding sites of TRPC6 could potentially facilitate future design of drugs to treat TRPC6-mediated diseases.
    1. Ecology
    2. Evolutionary Biology

    Understanding the evolution of multiple drug resistance in structured populations

    David V McLeod, Sylvain Gandon
    The evolution of multidrug resistance can be most easily understood by focusing upon the dynamical equations of linkage disequilibrium.
    1. Structural Biology and Molecular Biophysics

    Structure of a low-population intermediate state in the release of an enzyme product

    Alfonso De Simone et al.
    Product release from human lysozyme is mediated by an intermediate state with transient weak interactions between the product and enzyme.
    1. Genetics and Genomics
    2. Evolutionary Biology

    Admixture into and within sub-Saharan Africa

    George BJ Busby et al.
    Gene flow analysis reveals that the genomes of most sub-Saharan populations are the result of recent historical admixture events.
    1. Microbiology and Infectious Disease

    Experimentally guided models reveal replication principles that shape the mutation distribution of RNA viruses

    Michael B Schulte et al.
    A mathematical model that combines stochasticity and spatial structure describes the dynamics of the viral population during an infection cycle, and fitting the model to RNA and virus abundances over time shows that poliovirus follows a geometric replication mode.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The evolutionary history and genomics of European blackcap migration

    Kira Delmore et al.
    Variation in migration can evolve rapidly and traits that comprise this behaviour may be determined by standing variation at a few regulatory regions that are not common across taxonomic groups.

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