The probability of occupancy of individual synaptic release sites at rest sets an upper limit to synaptic output when increasing action potential related calcium entry.
The prediction accuracies of polygenic scores in humans vary depending on the characteristics of the samples, as well as based on the study design, within a single ancestry group.
Artur Meller, Jeffrey M Lotthammer ... Gregory R Bowman
A cryptic pocket in the myosin motor domain selectively opens in molecular dynamics simulations, and the probability of pocket opening is predictive of how potently a compound will inhibit a particular myosin motor.
Addressing the controversy regarding the interpretation of choice probabilities demonstrates that both readout strategy and noise correlations contribute to the link between neural activity and perceptual decisions.
Proteolytic maturation of auxiliary α2δ subunits of voltage-gated calcium channels increases neuronal communication by controlling the synaptic release of neurotransmitter.
Pia Schröder, Timo Torsten Schmidt, Felix Blankenburg
Neural correlates of somatosensory target detection are restricted to secondary somatosensory cortex, whereas activity in insular, cingulate, and motor regions reflects stimulus uncertainty and overt reports.