7,321 results found
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure in situ reveals a molecular switch that safeguards virus against genome loss

    Oliver W Bayfield et al.
    Structure of the portal protein of a thermostable virus, determined in its capsid-bound state, reveals a molecular mechanism that prevents DNA slippage during genome packaging.
    1. Cell Biology
    2. Evolutionary Biology

    Sterol transfer by atypical cholesterol-binding NPC2 proteins in coral-algal symbiosis

    Elizabeth Ann Hambleton et al.
    Diversification of a conserved cholesterol binder drives functional replacement of cholesterol with symbiont-produced sterols in corals living in nutrient-poor environments.
    1. Biochemistry and Chemical Biology

    Translation of 5′ leaders is pervasive in genes resistant to eIF2 repression

    Dmitry E Andreev et al.
    Most of the mRNAs whose translation is resistant to the stress-induced repression of protein synthesis contain upstream open reading frames that are efficiently translated under normal conditions.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Bacterial flagellar capping proteins adopt diverse oligomeric states

    Sandra Postel et al.
    The first high-resolution structure of a bacterial flagellar cap protein, FliD, reveals new insights into the assembly of bacterial flagella.
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Polypyrimidine tract-binding proteins are essential for B cell development

    Elisa Monzón-Casanova et al.
    The RNA-binding protein polypyrimidine tract-binding protein 1 (PTBP1) is essential for B cell development at the pro-B cell stage where it suppresses S-phase entry and promotes progression through mitosis.
    1. Cell Biology
    2. Developmental Biology

    Drosophila hedgehog can act as a morphogen in the absence of regulated Ci processing

    Jamie C Little et al.
    Hedgehog acts as a morphogen by regulating proteolytic processing and activation of full-length Ci/Gli transcriptional effectors but can pattern Drosophila wing discs normally in the absence of regulated proteolytic processing.
    1. Biochemistry and Chemical Biology

    Imaging and energetics of single SSB-ssDNA molecules reveal intramolecular condensation and insight into RecOR function

    Jason C Bell et al.
    Individual SSB-ssDNA complexes undergo reversible condensation and de-condensation that is modulated by RecOR during recombination.
    1. Cell Biology
    2. Neuroscience

    Restraint of presynaptic protein levels by Wnd/DLK signaling mediates synaptic defects associated with the kinesin-3 motor Unc-104

    Jiaxing Li et al.
    Synaptic defects previously attributed to loss of kinesin function are found to be mediated by the Wnd/DLK axonal injury signaling pathway, which restrains the total levels of presynaptic proteins in response to their accumulation.
    1. Computational and Systems Biology
    2. Cancer Biology

    Mitochondrial DNA copy number variation across human cancers

    Ed Reznik et al.
    Many tumors are depleted of mitochondrial DNA; this depletion is associated with changes in gene expression and with the incidence of critical somatic mutations and alterations.
    1. Cell Biology
    2. Immunology and Inflammation

    Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway

    Sudha Kumari et al.
    T cell receptor signaling is regulated by newly polymerized F-actin foci at the immunological synapse.

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