330 results found
    1. Cell Biology
    2. Neuroscience

    Golgi-independent secretory trafficking through recycling endosomes in neuronal dendrites and spines

    Aaron B Bowen et al.
    Neurons use a non-canonical secretory network to deliver select proteins to postsynaptic sites in dendrites.
    1. Cell Biology

    A bioactive peptide amidating enzyme is required for ciliogenesis

    Dhivya Kumar et al.
    Analysis of Chlamydomonas, planaria and mice reveals a novel and unanticipated role for a peptide amidating enzyme in primary and motile ciliary assembly through effects on post-Golgi trafficking.
    1. Cell Biology
    2. Plant Biology

    Delivery of endocytosed proteins to the cell–division plane requires change of pathway from recycling to secretion

    Sandra Richter et al.
    The same membrane trafficking cargo can change pathways mediated by different members of ARF-GEF family of vesicle formation regulators.
    1. Plant Biology

    Arabidopsis 14-3-3 epsilon members contribute to polarity of PIN auxin carrier and auxin transport-related development

    Jutta Keicher et al.
    Conditional genetic inactivation of a highly conserved, ancestral subgroup of 14-3-3 proteins in Arabidopsis thaliana reveals fundamental roles in auxin transport-dependent plant development and post-Golgi trafficking processes.
    1. Cell Biology
    2. Immunology and Inflammation

    UNC93B1 mediates differential trafficking of endosomal TLRs

    Bettina L Lee et al.
    A transmembrane protein uses distinct mechanisms to regulate the movement of specific toll-like receptors-key immune system components involved in detecting pathogens-to their final locations inside cells.
    1. Microbiology and Infectious Disease

    An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell

    Michael J Coffey et al.
    The Toxoplasma parasite requires an enzyme called ASP5 to cleave proteins for export into host cells.
    1. Plant Biology

    The manifold actions of signaling peptides on subcellular dynamics of a receptor specify stomatal cell fate

    Xingyun Qi et al.
    A binary cell fate decision to be or not to be stomata is regulated by multiple peptide ligands, each triggering a unique subcellular dynamics of their shared receptor.
    1. Developmental Biology

    A mammalian Wnt5a–Ror2–Vangl2 axis controls the cytoskeleton and confers cellular properties required for alveologenesis

    Kuan Zhang et al.
    Regulation of cellular properties such as ligand secretion and migratory ability through changes in the cytoskeleton mediated by a Wnt5a–Ror2–Vangl2 axis is a major determinant of alveolar formation.
    1. Cell Biology
    2. Developmental Biology

    The CHORD protein CHP-1 regulates EGF receptor trafficking and signaling in C. elegans and in human cells

    Andrea Haag et al.
    The co-chaperone CHORDC1 is specifically required for epidermal growth factor receptor trafficking and signaling in Caenorhabditis elegans and in human cells.
    1. Cell Biology

    Genome-wide interrogation of extracellular vesicle biology using barcoded miRNAs

    Albert Lu et al.
    A screen using artificially barcoded, exosomal microRNAs, paired with CRISPR guide RNAs, helped identify new players in multivesicular endosome exocytosis and a role for Wnt signaling.

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