Human yolk sac-like cells, which share characteristics with the post-implantation human hypoblast, can model the interaction between the epiblast and hypoblast that occurs during early human development.

Post-implantation epiblast maturation and patterning of anterior-posterior axis in mouse embryonic development are mediated by pluripotency transcription factor Zfp281 through transcriptional and epigenetic control of Nodal signaling.

Techniques are presented to facilitate widespread and standardized chronic use of Neuropixels probes for high-yield, long-term neural recording in freely moving animals.

A well-trained deep learning neural network can outperform and can potentially assist expertly trained embryologists in selecting embryos based on their implantation potential, even amongst high-quality euploid blastocyst embryos.

Naive hPSCs can readily give rise to human trophoblast stem cells, thus demonstrating their extraembryonic lineage potential and providing a new model system to study human trophectoderm specification.

A novel micropositioning approach allows remote-controlled, micrometer-resolution actuation of many densely packed, arbitrarily shaped probes with a device whose size and weight scale much more efficiently with probe count compared to current methods.

Innovative MRI mapping of the auditory pathway reveals that peripheral auditory structure significantly impacts the development of the central auditory-language network in children with profound sensorineural hearing loss, emphasizing the need for early speech input and tailored interventions.

Silencing of gene regulatory elements by modifications of DNA-bound proteins promotes the progression of early mouse development.

A novel lncRNA (Ephemeron) is connected to known post-transcriptional and epigenetic regulators as part of an integrated machinery, which controls the timely exit from the naïve state of mouse embryonic stem cells.