491 results found
    1. Developmental Biology

    Zfp281 is essential for mouse epiblast maturation through transcriptional and epigenetic control of Nodal signaling

    Xin Huang et al.
    Post-implantation epiblast maturation and patterning of anterior-posterior axis in mouse embryonic development are mediated by pluripotency transcription factor Zfp281 through transcriptional and epigenetic control of Nodal signaling.
    1. Medicine

    Performance of a deep learning based neural network in the selection of human blastocysts for implantation

    Charles L Bormann et al.
    A well-trained deep learning neural network can outperform and can potentially assist expertly trained embryologists in selecting embryos based on their implantation potential, even amongst high-quality euploid blastocyst embryos.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Chromatin dynamics and the role of G9a in gene regulation and enhancer silencing during early mouse development

    Jan J Zylicz et al.
    Silencing of gene regulatory elements by modifications of DNA-bound proteins promotes the progression of early mouse development.
    1. Stem Cells and Regenerative Medicine

    Derivation of trophoblast stem cells from naïve human pluripotent stem cells

    Chen Dong et al.
    Naive hPSCs can readily give rise to human trophoblast stem cells, thus demonstrating their extraembryonic lineage potential and providing a new model system to study human trophectoderm specification.
    1. Developmental Biology
    2. Genetics and Genomics

    Smchd1 is a maternal effect gene required for genomic imprinting

    Iromi Wanigasuriya et al.
    Imprinted gene expression is set up during a critical window of early embryonic development, by the translation of parental imprints by oocyte-supplied Smchd1 into allele-specific gene silencing.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    High-resolution transcriptional and morphogenetic profiling of cells from micropatterned human ESC gastruloid cultures

    Kyaw Thu Minn et al.
    Micropatterned differentiation of human ESCs generates gastrulation cell types – germ layers, extraembryonic, and primordial germ cells with primate characteristics – that show conserved sorting behaviors when dissociated and reseeded as single-cell mixture.
    1. Evolutionary Biology
    2. Genetics and Genomics

    A de novo evolved gene in the house mouse regulates female pregnancy cycles

    Chen Xie et al.
    A female specifically expressed new protein-coding gene that has emerged out of non-coding sequences without detectable signatures of adaptive evolution affects female pregnancy cycles.
    1. Developmental Biology

    A lncRNA fine tunes the dynamics of a cell state transition involving Lin28, let-7 and de novo DNA methylation

    Meng Amy Li et al.
    A novel lncRNA (Ephemeron) is connected to known post-transcriptional and epigenetic regulators as part of an integrated machinery, which controls the timely exit from the naïve state of mouse embryonic stem cells.
    1. Neuroscience

    Hippocampal pattern completion is linked to gamma power increases and alpha power decreases during recollection

    Bernhard P Staresina et al.
    Direct recordings from the human hippocampus reveal the neural mechanisms that orchestrate recollection of past experiences.
    1. Stem Cells and Regenerative Medicine

    Distinct SoxB1 networks are required for naïve and primed pluripotency

    Andrea Corsinotti et al.
    Genetic manipulations show that endogenous transcription factors of the SoxB1 class act redundantly to maintain primed pluripotency and reveal differential effects on transitions between pluripotent and differentiation states.

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