3,319 results found
    1. Evolutionary Biology

    Multifactorial processes underlie parallel opsin loss in neotropical bats

    Alexa Sadier et al.
    Parallel losses of short-wave light sensitivity in diverse bats occurred through independent changes at multiple steps in the conversion of genotype into functional phenotype, including pre-, during, and post-transcription.
    1. Structural Biology and Molecular Biophysics

    Transcription: Overcoming chromatin barriers

    Babette E de Jong, John van Noort
    Single-molecule experiments reveal the dynamics of transcription through a nucleosome with single-base-pair accuracy.
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    1. Developmental Biology
    2. Genetics and Genomics

    Neurogenesis: Silencing the alternative

    Priya Sivaramakrishnan, John Isaac Murray
    The transcription factor ztf-11 promotes neuronal differentiation by repressing other cell fates in the nematode worm C. elegans.
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    1. Chromosomes and Gene Expression

    Genome Organization: Painting chromosomes in the nucleus

    Cori K Cahoon, Diana E Libuda
    A multiplexed approach to DNA FISH experiments has been used to visualize the three-dimensional organization of chromosomes and specific chromosomal regions in C. elegans..
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    1. Microbiology and Infectious Disease

    Tropical Diseases: Can CRISPR help in the fight against parasitic worms?

    Paul McVeigh, Aaron G Maule
    The first reports of CRISPR/Cas9 genome editing in flatworms could usher in a new era of research on these dangerous human parasites.
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    1. Computational and Systems Biology

    Point of View: Data science for the scientific life cycle

    Daphne Ezer, Kirstie Whitaker
    Each stage of the scientific life cycle stands to benefit from the introduction of data science techniques.
    1. Cell Biology
    2. Neuroscience

    2018 Gairdner Awards: The past, present and future of light-gated ion channels and optogenetics

    Sheena A Josselyn
    Research into light-gated ion channels called channelrhodospins laid the foundations for the development of optogenetics, a technique that has gone on to revolutionize neuroscience.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Viruses: The secrets of the stability of the HIV-1 capsid

    Martin Obr, Hans-Georg Kräusslich
    Structural and biophysical studies help to follow the disassembly of the HIV-1 capsid in vitro, and reveal the role of a small molecule called IP6 in regulating capsid stability.
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    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Metabolism: Division of labor in bacteria

    Alma Dal Co et al.
    The emergence of subpopulations that perform distinct metabolic roles has been observed in populations of genetically identical bacteria.
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    1. Developmental Biology

    Development: Cell death machinery makes life more robust

    Cristina Aguirre-Chen, Christopher M Hammell
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