3,679 results found
    1. Evolutionary Biology

    Multifactorial processes underlie parallel opsin loss in neotropical bats

    Alexa Sadier, Kalina TJ Davies ... Karen E Sears
    Parallel losses of short-wave light sensitivity in diverse bats occurred through independent changes at multiple steps in the conversion of genotype into functional phenotype, including pre-, during, and post-transcription.
    1. Stem Cells and Regenerative Medicine

    Proteomic analysis of young and old mouse hematopoietic stem cells and their progenitors reveals post-transcriptional regulation in stem cells

    Balyn W Zaro, Joseph J Noh ... Irving L Weissman
    Mass spectrometry exposes a post-transcriptionally regulated reduction in protein diversity in hematopoietic stem cells, including a lack of detectable Dnmt3a protein levels despite mRNA levels comparable to progenitors.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Profiling the bloodstream form and procyclic form Trypanosoma brucei cell cycle using single-cell transcriptomics

    Emma M Briggs, Catarina A Marques ... Keith R Matthews
    Single-cell transcriptomics of cryopreserved parasites reveals extensive cyclic regulation of mRNA abundance by Trypanosoma brucei during the cell cycle.
    1. Genetics and Genomics

    Quantitative proteomics reveals key roles for post-transcriptional gene regulation in the molecular pathology of facioscapulohumeral muscular dystrophy

    Sujatha Jagannathan, Yuko Ogata ... Robert K Bradley
    The myopathic transcription factor DUX4 induces discordant dysregulation of transcript and protein levels, demonstrating a key role for post-transcriptional gene regulation in facioscapulohumeral muscular dystrophy.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Hfq CLASH uncovers sRNA-target interaction networks linked to nutrient availability adaptation

    Ira Alexandra Iosub, Robert Willem van Nues ... Sander Granneman
    High-throughput RNA-RNA interaction analysis uncovers many novel sRNA-target interactions at various growth stages in Escherichia coli.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Nascent-Seq reveals novel features of mouse circadian transcriptional regulation

    Jerome S Menet, Joseph Rodriguez ... Michael Rosbash
    Genome-wide measurements on mouse liver cells show that transcription, and a particular key transcription factor, have a smaller than expected influence on the mouse circadian system.
    1. Computational and Systems Biology

    Quantifying how post-transcriptional noise and gene copy number variation bias transcriptional parameter inference from mRNA distributions

    Xiaoming Fu, Heta P Patel ... Ramon Grima
    A combined experimental and modeling approach provides insight into potential biases when inferring transcription rates from static mRNA distributions, and shows that correcting for cell-cycle phase and post-transcriptional noise provides rates that agree with live-cell transcription measurements.
    1. Physics of Living Systems

    Predictive modeling reveals that higher-order cooperativity drives transcriptional repression in a synthetic developmental enhancer

    Yang Joon Kim, Kaitlin Rhee ... Hernan G Garcia
    The combination of theoretical modeling and quantitative live imaging revealed that the repressor proteins work cooperatively or anti-cooperatively depending on enhancer architecture.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    RNase III-mediated processing of a trans-acting bacterial sRNA and its cis-encoded antagonist

    Sarah Lauren Svensson, Cynthia Mira Sharma
    Functional characterization of a pair of cis-encoded antisense RNAs reveals a role for RNase III and antisense regulation in the biogenesis and regulatory activity of a bacterial virulence factor-regulating small RNA.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Circadian RNA expression elicited by 3’-UTR IRAlu-paraspeckle associated elements

    Manon Torres, Denis Becquet ... Anne-Marie François-Bellan
    Circadian gene expression can be driven by a post-transcriptional mechanism involving circadian mRNA nuclear retention by paraspeckle nuclear bodies.

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