Parallel losses of short-wave light sensitivity in diverse bats occurred through independent changes at multiple steps in the conversion of genotype into functional phenotype, including pre-, during, and post-transcription.
Mass spectrometry exposes a post-transcriptionally regulated reduction in protein diversity in hematopoietic stem cells, including a lack of detectable Dnmt3a protein levels despite mRNA levels comparable to progenitors.
Emma M Briggs, Catarina A Marques ... Keith R Matthews
Single-cell transcriptomics of cryopreserved parasites reveals extensive cyclic regulation of mRNA abundance by Trypanosoma brucei during the cell cycle.
Sujatha Jagannathan, Yuko Ogata ... Robert K Bradley
The myopathic transcription factor DUX4 induces discordant dysregulation of transcript and protein levels, demonstrating a key role for post-transcriptional gene regulation in facioscapulohumeral muscular dystrophy.
Jerome S Menet, Joseph Rodriguez ... Michael Rosbash
Genome-wide measurements on mouse liver cells show that transcription, and a particular key transcription factor, have a smaller than expected influence on the mouse circadian system.
A combined experimental and modeling approach provides insight into potential biases when inferring transcription rates from static mRNA distributions, and shows that correcting for cell-cycle phase and post-transcriptional noise provides rates that agree with live-cell transcription measurements.
The combination of theoretical modeling and quantitative live imaging revealed that the repressor proteins work cooperatively or anti-cooperatively depending on enhancer architecture.
Functional characterization of a pair of cis-encoded antisense RNAs reveals a role for RNase III and antisense regulation in the biogenesis and regulatory activity of a bacterial virulence factor-regulating small RNA.