2,034 results found
    1. Microbiology and Infectious Disease

    Dynamic post-translational modification profiling of Mycobacterium tuberculosis-infected primary macrophages

    Jonathan M Budzik et al.
    Measurement of post-translational modifications in primary macrophages infected with Mtb revealed phosphorylation of TAX1BP1, an autophagy receptor that enables full maturation of the Mtb autophagosome.
    1. Chromosomes and Gene Expression

    Exploration of CTCF post-translation modifications uncovers Serine-224 phosphorylation by PLK1 at pericentric regions during the G2/M transition

    Brian C Del Rosario et al.
    The chromosome architectural protein, CTCF, is phosphorylated at Ser224 in a cell-cycle-dependent manner and abrogation of phosphorylation leads to a cell growth defect.
    1. Cell Biology

    Site-specific phosphorylation and caspase cleavage of GFAP are new markers of Alexander disease severity

    Rachel A Battaglia et al.
    GFAP protein carries a distinct post-translational modification signature that facilitates its pathogenic accumulation and aggregation in astrocytes of patients who succumb to Alexander Disease very early in life.
    1. Structural Biology and Molecular Biophysics

    The inner junction complex of the cilia is an interaction hub that involves tubulin post-translational modifications

    Ahmad Abdelzaher Zaki Khalifa et al.
    A structure of the ciliary inner junction at 3.6 Å resolution permits atomic modeling of six inner junction proteins and their interactions with acetylated lysine 40 loops of alpha tubulins.
    1. Plant Biology

    The biogenesis of CLEL peptides involves several processing events in consecutive compartments of the secretory pathway

    Nils Stührwohldt et al.
    Step-wise processing of plant peptide hormone precursors by subtilisin-like proteinases in consecutive compartments of the secretory pathway is required for formation and secretion of the bioactive peptides.
    1. Microbiology and Infectious Disease

    Post-translational thioamidation of methyl-coenzyme M reductase, a key enzyme in methanogenic and methanotrophic Archaea

    Dipti D Nayak et al.
    Post-translational installation of thioglycine in methyl-coenzyme M reductase in the methanogenic archaeon Methanosarcina acetivorans is mediated by the tfuA-ycaO locus and stabilizes the protein secondary structure near the active site.
    1. Microbiology and Infectious Disease

    Modifications at K31 on the lateral surface of histone H4 contribute to genome structure and expression in apicomplexan parasites

    Fabien Sindikubwabo et al.
    A versatile acetylation-methylation switch at lysine 31 on the lateral surface of histone H4 contributes to chromatin structure in apicomplexan parasites.
    1. Cell Biology

    Identification of ubiquitin Ser57 kinases regulating the oxidative stress response in yeast

    Nathaniel L Hepowit et al.
    Ser57 phosphorylation of ubiquitin protects the cell during proteotoxic stress.
    1. Developmental Biology

    m6A RNA methylation impacts fate choices during skin morphogenesis

    Linghe Xi et al.
    METTL3-mediated m6A modification maintains proper cell lineage specification during skin epithelium morphogenesis by coupling transcription and translation of key regulatory pathways.
    1. Cell Biology

    An extensive program of periodic alternative splicing linked to cell cycle progression

    Daniel Dominguez et al.
    Extensive periodic regulation of alternative splicing during the cell cycle in genes is linked to cell cycle functions, and involves an auto-inhibitory mechanism that uses the protein kinase CLK1.

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