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Targeted SOCS3 null mice reveal that maturation of cortical bone comprises both pore closure and accumulation of high density bone, requiring local suppression of gp130-STAT3 in osteocytes and subsequent osteoclastogenesis.

High reproductive effort constrains bone tissue response to physical activity-induced mechanical loading.

Bone formation in adult mice can be induced by a bone-binding, recombinant version of the Notch ligand Delta-like 4 without triggering adverse effects in other organs.

Molecular and biochemical approaches in primary human cells illustrate how a nuclear RNA-binding protein is shifted to the surface of osteoclasts – setting their size and biological activity.

Genetic variance of adult human height shows a generally increasing trend across the birth-year cohorts but heritability estimates do not present any clear pattern of secular changes over a century.

A GWAS meta-analysis for OPLL identified fourteen significant genomic loci and a subsequent Mendelian randomization study provided genetic evidence for a causal effect of obesity on the pathogenesis of OPLL, especially one of its subtypes, thoracic OPLL.

The interplay between the transcriptional co-regulators YAP1/TAZ and the hypoxia-controlled transcription factor HIF1α differentially regulates endothelial cell behavior in the hypoxic environment of bone compared to other organs.

Transferrin receptor 1-mediated iron uptake plays a pivotal role in osteoclast energy metabolism and cytoskeleton and regulates bone remodeling in female mice.

Mitochondrial Cx43 hemichannels regulate ATP generation by mediating K+, H+, and ATP transfer across the mitochondrial inner membrane and the interaction with mitochondrial ATP synthase, contributing to maintenance of mitochondrial redox and cell protection under oxidative stress.