101 results found
    1. Developmental Biology
    2. Neuroscience

    Dlk1-Dio3 locus-derived lncRNAs perpetuate postmitotic motor neuron cell fate and subtype identity

    Ya-Ping Yen et al.
    LncRNAs are important to stabilize postmitotic cell fate of spinal motor neurons.
    1. Developmental Biology
    2. Neuroscience

    Mutual inhibition among postmitotic neurons regulates robustness of brain wiring in Drosophila

    Marion Langen et al.
    The Notch signaling pathway has a central role in the development of the nervous system, and also in the establishment of networks of connections in the adult brain
    1. Cell Biology

    Time line of redox events in aging postmitotic cells

    Nicolas Brandes et al.
    A sudden fall in the levels of the coenzyme NADPH within cells could have a central role in the process of aging.
    1. Developmental Biology

    Critical roles of ARHGAP36 as a signal transduction mediator of Shh pathway in lateral motor columnar specification

    Heejin Nam et al.
    Shh, produced by postmitotic spinal neurons, plays crucial roles in the specification of the lateral motor column of the spinal cord through ARHGAP36.
    1. Genetics and Genomics

    Quiescence unveils a novel mutational force in fission yeast

    Serge Gangloff et al.
    The quiescence-driven mutational landscape reveals replication-independent mutagenesis as a novel evolutionary force.
    1. Cell Biology

    Stress-induced Cdk5 activity enhances cytoprotective basal autophagy in Drosophila melanogaster by phosphorylating acinus at serine437

    Nilay Nandi et al.
    Cdk5-mediated stabilization of Acinus in postmitotic neurons promotes autophagy and the removal of protein aggregates linked to neurodegeneration in Drosophila melanogaster.
    1. Neuroscience

    Neurogliaform cortical interneurons derive from cells in the preoptic area

    Mathieu Niquille et al.
    In vivo genetic lineage-tracing reveals the developmental trajectory of neurogliaform cells, the main effectors of a powerful inhibitory motif in the neocortex.
    1. Computational and Systems Biology
    2. Developmental Biology

    Elastic force restricts growth of the murine utricle

    Ksenia Gnedeva et al.
    Computational modeling and molecular-biological analysis reveal the role of mechanical force and downstream Yap signaling in growth control during the development and regeneration of sensory epithelium of the inner ear.
    1. Neuroscience

    Coordinated control of terminal differentiation and restriction of cellular plasticity

    Tulsi Patel, Oliver Hobert
    Transcription factors that specify the identity of individual neuron types via activating terminal differentiation gene batteries also restrict cellular plasticity via altering the chromatin landscape.
    1. Neuroscience

    A cellular and regulatory map of the cholinergic nervous system of C. elegans

    Laura Pereira et al.
    Analyzing a map of all cholinergic neurons in the nematode C. elegans shows how these neurons are embedded in the C. elegans connectome and reveals the regulatory factors controlling their development.

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