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    1. Neuroscience

    Improving a probabilistic cytoarchitectonic atlas of auditory cortex using a novel method for inter-individual alignment

    Omer Faruk Gulban, Rainer Goebel ... Federico de Martino
    Inter-individual human brain alignment that uses macro-anatomical priors in addition to cortical curvature improves micro-anatomical correspondence between auditory areas.
    1. Neuroscience

    Unique membrane properties and enhanced signal processing in human neocortical neurons

    Guy Eyal, Matthijs B Verhoog ... Idan Segev
    Models and experiments reveal that human L2/3 pyramidal neurons have distinctively low specific membrane capacitance which might have a significant impact on signal processing in human neocortex.
    1. Genetics and Genomics
    2. Neuroscience

    Antipsychotic-induced epigenomic reorganization in frontal cortex of individuals with schizophrenia

    Bohan Zhu, Richard I Ainsworth ... Javier González-Maeso
    Age and antipsychotic treatment effects on chromatin organization in the frontal cortex of schizophrenia subjects.
    1. Neuroscience

    Increased expression of heme-binding protein 1 early in Alzheimer's disease is linked to neurotoxicity

    Oleksandr Yagensky, Mahdokht Kohansal-Nodehi ... John JE Chua
    Increased levels of brain Hebp1 starting from the presymptomatic stage of Alzheimer’s disease contributes to progressive neuronal loss by triggering mitochondrial-dependent apoptosis in neurons exposed to elevated heme.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Single-cell ‘omic profiles of human aortic endothelial cells in vitro and human atherosclerotic lesions ex vivo reveal heterogeneity of endothelial subtype and response to activating perturbations

    Maria L Adelus, Jiacheng Ding ... Casey E Romanoski
    Primary endothelial cell cultures contain markedly heterogeneous cell subtypes that exhibit distinct molecular responses to disease-relevant exposures.
    1. Cell Biology
    2. Neuroscience

    The cryptic gonadotropin-releasing hormone neuronal system of human basal ganglia

    Katalin Skrapits, Miklós Sárvári ... Erik Hrabovszky
    Neuroanatomical studies reveal presence and cholinergic phenotype of 150,000-200,000 extrahypothalamic gonadotropin-releasing hormone neurons in human basal ganglia and basal forebrain, and RNA-sequencing detects gonadotropin-releasing hormone receptor-1 expression in cholinergic interneurons but not in spiny projection neurons of the human putamen.
    1. Neuroscience

    Cortical tau deposition follows patterns of entorhinal functional connectivity in aging

    Jenna N Adams, Anne Maass ... William J Jagust
    Tau deposition in the aging brain follows patterns of functional connectivity that correspond to specific neural memory networks, and this relationship is strengthened in the presence of amyloid-β.
    1. Biochemistry and Chemical Biology

    The ‘ForensOMICS’ approach for postmortem interval estimation from human bone by integrating metabolomics, lipidomics, and proteomics

    Andrea Bonicelli, Hayley L Mickleburgh ... Noemi Procopio
    The integration of multiple omics panels obtained from bone tissue could aid in the evaluation of the postmortem interval in forensic investigations, expanding the boundaries of forensic research.
    1. Neuroscience

    Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription

    Rui Gao, Anirban Chakraborty ... Partha S Sarkar
    Polyglutamine expansion in mutant huntingtin disrupts a novel transcription-coupled DNA repair complex, providing an undescribed mechanism of neuronal toxicity and degeneration in Huntington's disease.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    eIF2B activator prevents neurological defects caused by a chronic integrated stress response

    Yao Liang Wong, Lauren LeBon ... Carmela Sidrauski
    Boosting the function of translation factor eIF2B by chronic small molecule administration prevents pathology in a neurodegenerative model of Vanishing White Matter disease characterized by a maladaptive stress response.