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Biophysics of object segmentation in a collision-detecting neuron
Richard Burkett Dewell, Fabrizio Gabbiani
Active dendritic processing enables an individual neuron to discriminate the spatial pattern of synaptic inputs, increasing neural and behavioral selectivity for escaping an impending threat.
Orphan receptor GPR158 controls stress-induced depression
Laurie P Sutton et al.
The orphan receptor GPR158 is highly regulated by stress exposure and acts on key neuronal signaling pathways in the prefrontal cortex to control depressive-like behaviors.
Neuropathological and transcriptomic characteristics of the aged brain
Jeremy A Miller et al.
High variability in neuropathology burden and interactions between dementia diagnosis and RNA quality present underappreciated complications when studying dementia in an aged population.
Unique membrane properties and enhanced signal processing in human neocortical neurons
Guy Eyal et al.
Models and experiments reveal that human L2/3 pyramidal neurons have distinctively low specific membrane capacitance which might have a significant impact on signal processing in human neocortex.
NPTX2 and cognitive dysfunction in Alzheimer’s Disease
Mei-Fang Xiao et al.
Dysfunction of pyramidal neuron-PV interneuron circuits contributes to cognitive failure in Alzheimer's disease.
MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders
Adam J Harrington et al.
Mice that lack the autism- and schizophrenia-linked gene
in cortical neurons have an imbalance of excitatory and inhibitory synapses, and impaired social and cognitive abilities.
Layer 2/3 pyramidal cells in the medial prefrontal cortex moderate stress induced depressive behaviors
Prerana Shrestha et al.
The well-established link between stress and depression could be due to the activity of a population of cells in prefrontal cortex that express a gene mutated in the rare disorder Wolfram syndrome.
Immunology and Inflammation
Cytotoxic T-cells mediate exercise-induced reductions in tumor growth
Helene Rundqvist et al.
Exercise can induce metabolic changes that strikingly impact cytotoxic T cell function and in turn affect cancer progression.
Immunology and Inflammation
A novel role for lipoxin A
in driving a lymph node–eye axis that controls autoimmunity to the neuroretina
Jessica Wei et al.
in lymph nodes is an important resident homeostatic regulator that controls effector T cell functions and egress in the development of adaptive immune responses.
Physics of Living Systems
Mitigating memory effects during undulatory locomotion on hysteretic materials
Perrin E Schiebel et al.
Undulatory animals moving on the surface must manage material memory by either having a slender anatomy that facilitates avoiding previously remodeled substrate, or using waveshapes that effectively utilize the memory.
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