336 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Serine phosphorylation regulates the P-type potassium pump KdpFABC

    Marie E Sweet et al.
    Phosphorylation of a highly conserved serine residue is a physiological response of Escerichia coli to environmental potassium levels that inhibits transport by KdpFABC to maintain cellular homeostasis.
    1. Neuroscience

    Deletion of KCNQ2/3 potassium channels from PV+ interneurons leads to homeostatic potentiation of excitatory transmission

    Heun Soh et al.
    Loss of potassium channel activity from fast-spiking interneurons increases their excitability leading to unexpectedly increased fast excitatory transmission and seizure susceptibility.
    1. Cell Biology

    Potassium dependent rescue of a myopathy with core-like structures in mouse

    M Gartz Hanson et al.
    A mouse model of human muscle myopathy is used to provide mechanistic insight, identify possible biomarkers of disease, and suggest possible therapeutic strategies to alleviate muscle weakness.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Dyshomeostatic modulation of Ca2+-activated K+ channels in a human neuronal model of KCNQ2 encephalopathy

    Dina Simkin et al.
    An inducedpluripotent stem cell (iPSC)-based model of KCNQ2-associated developmental epileptic encephalopathy suggests that disease is driven by dyshomeostaic neuronal mechanisms that are downstream of loss of M-current.
    1. Cell Biology
    2. Plant Biology

    A receptor-like kinase mutant with absent endodermal diffusion barrier displays selective nutrient homeostasis defects

    Alexandre Pfister et al.
    The SCHENGEN3 protein is needed for the progression of isolated microdomains into a continuous band, which is necessary for the establishment of the major extracellular diffusion barrier in plant roots: the Casparian strip.
    1. Computational and Systems Biology
    2. Neuroscience

    Biophysical models reveal the relative importance of transporter proteins and impermeant anions in chloride homeostasis

    Kira M Düsterwald et al.
    Mathematical models with experimental validation show that chloride transporters in the cell membrane, and not negatively charged impermeant molecules, generate the driving force used by GABA receptors to silence neurons.
    1. Ecology
    2. Genetics and Genomics

    Novel adverse outcome pathways revealed by chemical genetics in a developing marine fish

    Elin Sørhus et al.
    Global gene expression analysis unravels the underlying mechanisms for distinct crude oil induced defects in Atlantic haddock eggs and larvae.
    1. Neuroscience

    Noise-induced plasticity of KCNQ2/3 and HCN channels underlies vulnerability and resilience to tinnitus

    Shuang Li et al.
    Mice that successfully avoid developing tinnitus despite exposure to excessive noise show spontaneous recovery of KCNQ2/3 potassium channel activity associated with a reduction in HCN channel activity in auditory brainstem neurons.
    1. Cell Biology

    Age-dependent diastolic heart failure in an in vivo Drosophila model

    Matthew P Klassen et al.
    As in humans, Drosophila hearts are able to maintain contractile performance during healthy aging, but this maintenance is associated with an increased susceptibility to progressive dysrhythmias that can lead to fibrillatory arrest.
    1. Neuroscience

    Early intrinsic hyperexcitability does not contribute to motoneuron degeneration in amyotrophic lateral sclerosis

    Félix Leroy et al.
    Contrary to a long-standing hypothesis, the neuronal death that leads to muscle wastage in amyotrophic lateral sclerosis does not result from overactivity of those neurons during development.

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