6,022 results found
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Kinesin motility is driven by subdomain dynamics

    Wonmuk Hwang, Matthew J Lang, Martin Karplus
    The motor protein kinesin utilizes its fuel molecule by active and concerted motions of its subdomains, while it rapidly interacts with the microtubule track by forming a wet and dynamic interface.
    1. Neuroscience
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    Science Forum: Ten common statistical mistakes to watch out for when writing or reviewing a manuscript

    Tamar R Makin, Jean-Jacques Orban de Xivry
    What can authors and reviewers do to keep common statistical mistakes out of the literature?
    1. Structural Biology and Molecular Biophysics

    Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate

    Xue Fei, Tristan A Bell ... Robert T Sauer
    Cryo-EM structures of the ClpXP protease reveal how protein substrates are bound, show how spiral ClpX hexamers bind symmetry-mismatched heptameric ClpP rings, and suggest mechanisms for processive substrate translocation.
    1. Neuroscience
    2. Physics of Living Systems

    Scale-free behavioral dynamics directly linked with scale-free cortical dynamics

    Sabrina A Jones, Jacob H Barfield ... Woodrow L Shew
    Complex, multi-scale natural behaviors may arise from subpopulations of neurons in cerebral cortex operating near the tipping point of a phase transition, that is, near criticality.
  1. Living Science: Power analysis

    Indira M Raman
    After acknowledging that power differentials exist, can scientists find inspiration to persevere anyway?
    1. Structural Biology and Molecular Biophysics

    Unmasking coupling between channel gating and ion permeation in the muscle nicotinic receptor

    John R Strikwerda, Steven M Sine
    Mutating a highly conserved intramembrane salt bridge unmasks structural and functional coupling between channel gating and ion permeation in the muscle nicotinic receptor.
    1. Genetics and Genomics

    Limitations of principal components in quantitative genetic association models for human studies

    Yiqi Yao, Alejandro Ochoa
    It is always better to use mixed effects models over principal components association regression for genetic association studies of continuous traits, since the former models family structure and close relatives are always found in real human studies.
    1. Neuroscience

    Inter-individual differences in human brain structure and morphology link to variation in demographics and behavior

    Alberto Llera, Thomas Wolfers ... Christian F Beckmann
    Multi-modal structural data fusion questions the specificity of fMRI-behavior associations by providing strong evidence relating human brain structure to a wide range of behavioral measures previously associated to functional connectivity.
    1. Neuroscience

    Distinct population code for movement kinematics and changes of ongoing movements in human subthalamic nucleus

    Dennis London, Arash Fazl ... Roozbeh Kiani
    Subthalamic nucleus spiking activity, beta oscillation power, and locking of spikes to the beta oscillation are decreased prior to changes in ongoing movements.
    1. Structural Biology and Molecular Biophysics

    Three dimensional reconstruction of energy stores for jumping in planthoppers and froghoppers from confocal laser scanning microscopy

    Igor Siwanowicz, Malcolm Burrows
    Three dimensional reconstructions of the mechanical energy stores of jumping insects reveal how the miniaturized components interact and function.

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