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Labeling with ¹³C and ¹⁵N in the absence of metabolic engineering enabled the exploration of peptidoglycan metabolism at a very fine level of detail based on kinetic characterization of isotopologues predicted to occur according to known recycling and biosynthesis pathways.

Microbial variants that arise during chronic lung infections have an increased ability to use nutrients that are abundant in lung infections.

Guanosine tetraphosphate (ppGpp) is a pivotal regulator of chloroplast activity that is required for acclimation to nitrogen limitation in the model plant Arabidopsis.

Under starvation conditions, anti-carD antisense RNA and Clp protease work together to decrease the CarD level to mediate the adaptation and survival of mycobacterial cells.

Single-molecule fluorescence experiments reveal transcription initiation proceeds via a 'bind-unwind-load-and-lock' mechanism where promoter DNA unwinds outside the RNA polymerase (RNAP) cleft, the unwound template-DNA loads into the cleft, and RNAP 'locks' the template-DNA by closing the RNAP clamp module.

Biochemical and genome-wide analysis demonstrates that m¹G37 is important for tRNA aminoacylation and for the entire elongation cycle of protein synthesis.

Genetic and biochemical approaches uncover a novel mode of regulation of the alarmone synthetase RelA through a functional and direct interaction with the small subunit of the nitrite reductase NirD.

RNA polymerase recruits the PcrA DNA helicase via a conserved interaction motif in order to remove R-loops and prevent conflicts with replication.

Reengineering the nucleotide-binding pocket of an extant ATPase to restore ancestral GTPase activity revealed an ATP-dependent intermediate required for function and suggested why the protein evolved to use ATP.

Vibrio cholerae uses a conserved ribosome assembly factor to repress biofilm formation at low temperatures.