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    1. Developmental Biology
    2. Neuroscience

    Adult-born neurons modify excitatory synaptic transmission to existing neurons

    Elena W Adlaf, Ryan J Vaden ... Linda Overstreet-Wadiche
    The formation of new neurons in the adult dentate gyrus causes a proportion of cortical neurons to transfer their existing connections to the newborn cells.
    1. Neuroscience

    Dendritic nonlinearities are tuned for efficient spike-based computations in cortical circuits

    Balázs B Ujfalussy, Judit K Makara ... Máté Lengyel
    Dendrites combine the inputs that they receive from other neurons using calculations that have been optimized for those particular input patterns.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    HIV-1 uncoating by release of viral cDNA from capsid-like structures in the nucleus of infected cells

    Thorsten G Müller, Vojtech Zila ... Hans-Georg Kräusslich
    HIV-1 capsids enter the host cell nucleus, where they are partially disrupted to release the viral genome upon completion of reverse transcription.
    1. Developmental Biology

    Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage

    Marketa Kaucka, Tomas Zikmund ... Igor Adameyko
    The clonal oriented cell dynamics enables directional expansion and accurate scaling of sheet-like or rod-like cartilaginous elements and uncouples the mechanisms of elongation from thickness or diameter control.
    1. Neuroscience
    2. Physics of Living Systems

    A theory of synaptic transmission

    Bin Wang, Olga K Dudko
    The analytic theory establishes the general principles of synaptic transmission, enables extraction of microscopic parameters of synaptic fusion machinery from experiments, and links molecular constituents to synaptic function.
    1. Computational and Systems Biology
    2. Neuroscience

    BrainPy, a flexible, integrative, efficient, and extensible framework for general-purpose brain dynamics programming

    Chaoming Wang, Tianqiu Zhang ... Si Wu
    BrainPy presents a general-purpose programming framework that enables efficient implementation, simulation, training, and analysis of brain dynamics models across multiple organization scales, ultimately facilitating the understanding of the complex neural mechanisms underlying brain functions.
    1. Neuroscience

    Large-scale replication study reveals a limit on probabilistic prediction in language comprehension

    Mante S Nieuwland, Stephen Politzer-Ahles ... Falk Huettig
    Large-scale replication study with brain potentials challenges the view that people routinely predict the phonological form of a predictable word during language comprehension.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Structure of a Holliday junction complex reveals mechanisms governing a highly regulated DNA transaction

    Gurunathan Laxmikanthan, Chen Xu ... Gregory D Van Duyne
    The structure of a multi-protein DNA recombination reaction intermediate reveals how regulation is achieved by protein-mediated DNA wrapping around a core enzyme-substrate complex.
    1. Biochemistry and Chemical Biology

    Prefabrication of a ribosomal protein subcomplex essential for eukaryotic ribosome formation

    Cohue Peña, Sabina Schütz ... Vikram G Panse
    The ATPase Fap7 prefabricates a uS11:eS26 ribosomal protein complex for ribosome assembly.
    1. Neuroscience

    Dendritic coincidence detection in Purkinje neurons of awake mice

    Christopher J Roome, Bernd Kuhn
    Simultaneous voltage and calcium two-photon imaging of Purkinje neuron dendrites in awake mice reveals multiple interplaying mechanisms underlying sensory-evoked dendritic coincidence detection of parallel fiber and climbing fiber input.