1,862 results found
    1. Cell Biology

    An alternative splicing program promotes adipose tissue thermogenesis

    Santiago Vernia et al.
    NOVA pre-mRNA spacing factors suppress adipose tissue energy expenditure.
    1. Chromosomes and Gene Expression

    Exon junction complex proteins bind nascent transcripts independently of pre-mRNA splicing in Drosophila melanogaster

    Subhendu Roy Choudhury et al.
    Deposition of the exon junction complex is thought to be the missing link between pre-mRNA splicing and translation in multicellular organisms, but no evidence of such deposition has been found in Drosophila.
    1. Biochemistry and Chemical Biology

    Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP

    Andrea Pawellek et al.
    Hinokiflavone is identified as a splicing modulator that blocks progression from spliceosome complex A to complex B and inhibits SUMO protease SENP1, causing hyper-SUMOylation affecting 6 U2 snRNP proteins.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Requirement for highly efficient pre-mRNA splicing during Drosophila early embryonic development

    Leonardo Gastón Guilgur et al.
    The need for efficient pre-RNA splicing during early embryonic development of Drosophila indicates that the constraints imposed by the cell cycle are a force capable of driving changes in Eukaryotic gene architecture.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Striking circadian neuron diversity and cycling of Drosophila alternative splicing

    Qingqing Wang et al.
    Diverse and widespread novel alternative pre-mRNA splicing isoforms as well as cycling alternative splicing events that undergo time-of-day dependent changes are identified in isolated Drosophila neuron groups.
    1. Computational and Systems Biology

    The kinetics of pre-mRNA splicing in the Drosophila genome and the influence of gene architecture

    Athma A Pai et al.
    Surprising connections between gene architecture and splicing kinetics are illuminated using short, progressive metabolic labeling/RNA sequencing and novel computational modeling approaches in Drosophila cells.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Minor introns are embedded molecular switches regulated by highly unstable U6atac snRNA

    Ihab Younis et al.
    Hundreds of cell growth and stress response genes are controlled by a rare small RNA component of an ancient splicing machinery, providing a raison d'être for its previously unexplained evolutionary conservation.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    A new view of transcriptome complexity and regulation through the lens of local splicing variations

    Jorge Vaquero-Garcia et al.
    New methods reveal that complex local splicing variations are more prevalent in animals than previously appreciated, and demonstrate that local splicing variations are relevant for studies of development, gene regulation and neurodegenerative diseases.
    1. Chromosomes and Gene Expression

    Dose-dependent action of the RNA binding protein FOX-1 to relay X-chromosome number and determine C. elegans sex

    Behnom Farboud et al.
    RNA binding protein FOX-1 functions as a dose-dependent X-signal element to communicate X-chromosome number and determine nematode sex by controlling alternative non-productive pre-mRNA splicing of the master sex-determination switch gene.
    1. Structural Biology and Molecular Biophysics

    Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5′ splice site recognition

    Yasushi Kondo et al.
    The complete architecture of human spliceosomal U1 snRNP and its interaction with the 5′ splice site of pre-mRNA are described in atomic detail.

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