Jae Hun Shin, Jooyoung Park ... Alfred LM Bothwell
DKK2 is crucial for the development of lysozyme-expressing cancer cells with Paneth cell characteristics necessary for liver metastasized colon cancer growth.
Formation of a giant unilocular vacuole through a macropinocytosis-like process in cells with disrupted actin cytoskeleton promotes resistance to anoikis.
Eva M García-Cuesta, Pablo Martínez ... Mario Mellado
In silico modeling identify allosteric CXCR4 modulators that block receptor nanoclustering and chemoattractant sensing without affecting other CXCL12-mediated functions, and reduce tumorigenesis and metastasis in a zebrafish model.
Gregory Caleb Howard, Jing Wang ... William P Tansey
Analysis of the action of WDR5 inhibitors in leukemia cells reveals decreased ribosome inventory, impaired protein synthesis, induction of nucleolar stress, and activation of p53 via alternative splicing of MDM4.
A regionally resolved single-cell RNA-sequencing analysis of GBM-associated leukocytes reveals distinct activation states of the main immune populations between tumor center, peripheral infiltration zone and blood.
Cancer-directed treatment using Tumor-Treating Fields spatially modulates the tumor microenvironment at the cellular and molecular levels, decreasing nanotube-based cellular networks of communication while creating a microenvironment more susceptible to immunotherapeutic strategies.
