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In the absence of ROCK1 activation by caspases, apoptotic cells don’t undergo typical morphological changes, leading to sterile inflammation in the liver that increases tissue damage and suppresses tumor formation.

The chemokine CXCL13 is critical to the development of air pollution- and tobacco smoke-induced lung cancers.

The clinically approved HER2 inhibitor lapatinib causes HER2 and HER3 kinase domains to dimerise in a non-canonical, symmetric orientation, providing a platform for oligomerisation and predisposing to receptor-driven cell proliferation.

Breast cancer resistant to either doxorubicin or epirubicin relies on distinct primary metabolic processes, which can be targeted to reduce cancer progression.

Pre-neoplastic cells in the brain release SDF1, which mediates an immediate infiltration of macrophages that differentiate into microglia-like cells and promote proliferation of pre-neoplastic cells.

Proper gut health depends on the balance between two naturally occurring variants of a transcription factor in the colon.

A novel opioid formulation producing analgesia similar to conventional opioids without permeation of blood-brain or intestinal barriers, thus precluding sedation, constipation and respiratory depression.

A synthetic quadrastable gene network provides a synthetic biology framework to study cell fate determination.

Loss of Inverted Formin-2 impairs intracellular trafficking and trophoblast invasion, resulting in maternal hypertension and intrauterine growth restriction, which represents a novel model of impaired placental invasion that encompasses critical aspects of the great obstetrical syndromes.